[Home ] [Archive]    
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 5, Issue 1 (February 2019) ::
RABMS 2019, 5(1): 18-29 Back to browse issues page
Effect of probiotics on quality of life and depression in pregnant women with gestational diabetes: A randomized double-blinded clinical trial
Neda Dolatkhah , Majid Hajifaraji , Fatemeh Abbasalizadeh , Naser Aghamohammadzadeh , Fatemeh Jahanjou , Seyed Kazem Shakouri
Assistant Professor, Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran , neda_dolatkhah@yahoo.com
Abstract:   (240 Views)
Background & Aims:  Women are vulnerable and face variety of problems during pregnancy that can affect mental health and life quality. Pregnancy complications make pregnant women more prone to loss of quality of life and mental health problems. The purpose of this study was to investigate the effect of probiotic supplement on quality of life and depression in women with gestational diabetes mellitus (GDM).
Materials & Methods: In this double blind randomized clinical trial, performed on pregnant women with GDM referring to the specialized centers of gynecology and endocrinology in Tabriz, 64 pregnant women with GDM in 24-28 weeks of pregnancy were randomly assigned to receive either probiotic supplementation or placebo for 8 weeks. Probiotic supplement was a combination of four strains of Lactobacillus acidophilus, Bifidobacterium, Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. The short form of Iranian species of World Health Organization Quality of Life Questionnaire was used to assess the quality of life and the Edinburgh Depression Inventory to assess depression before and after intervention.
Results: Fifty six surveyed individuals completed the study. The effect of probiotic supplementation on changes in the physical dimension of quality of life was significant, with statistically remarkable increase of 2.59 ± 2.19 units in the probiotic group compared with 2.25 ± 0.88 decrease in the placebo group (p = 0.045). Also, the increase in mean of total quality of life in the probiotic group was 5.17 ± 1.46 units which was significant compared with 0.46 ± 1.61 units increase in the placebo group (p = 0.029). The effect of probiotic supplementation in comparison with placebo was significant in improving depression (p = 0.042).
Conclusions: It seems that probiotic supplementation promotes quality of life and depression levels in pregnant women with GDM.
Registration number in Iranian Registry of Clinical Trials: IRCT201405181597N3
 
Keywords: Gestational diabetes mellitus, Probiotic, Quality of life, Depression
Full-Text [PDF 939 kb]   (73 Downloads)    
Type of Study: orginal article | Subject: Special
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Jahanjou F, Shakouri S K. Effect of probiotics on quality of life and depression in pregnant women with gestational diabetes: A randomized double-blinded clinical trial. RABMS. 2019; 5 (1) :18-29
URL: http://ijrabms.umsu.ac.ir/article-1-78-en.html


Volume 5, Issue 1 (February 2019) Back to browse issues page
International Journal of Research in Applied and Basic Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3977