[Home ] [Archive]    
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 3, Issue 1 (October 2017) ::
RABMS 2017, 3(1): 1-10 Back to browse issues page
Tracking of the Maillard reaction products in oral liquid formulation of sertraline hydrochloride
Faranak Ghaderi , Mahboob Nemati , Mohammad reza Siahi , Hadi Valizadeh , Farnaz Monajjemzadeh
Department of Pharmaceutics, Tabriz University of Medical Sciences, Faculty of pharmacy, Tabriz, Iran , monajjemzadehf@yahoo.com
Abstract:   (288 Views)
In the present paper the physicochemical incompatibility of sertraline with dextrose was evaluated in oral liquid formulations. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and mass spectrometry were applied to assess sertraline - dextrose incompatibility. Non-Isothermally stressed physical mixtures were used to study the solid–state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) were used to calculate the activation energy of drug-excipient interaction.
The aim of this study was to evaluate the kinetic parameters using a fast and sensitive DSC method.
Overall, the incompatibility of sertraline as an amine containing drug with dextrose as a reducing carbohydrate was successfully evaluated. DSC based kinetic analysis can provide rapid and easy evaluation of different drug-excipient mixtures incompatibilities. Special considerations should be made regarding the Maillard incompatibility reaction in the formulation design of liquid formulations containing dextrose or natural herbal extracts as sweeteners.
 
Keywords: Sertraline, Dextrose, Incompatibility, Kinetic, DSC, Mass
Full-Text [PDF 954 kb]   (67 Downloads)    
Type of Study: orginal article | Subject: Special
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghaderi F, nemati M, siahi M R, valizadeh H, monajjemzadeh F. Tracking of the Maillard reaction products in oral liquid formulation of sertraline hydrochloride. RABMS. 2017; 3 (1) :1-10
URL: http://ijrabms.umsu.ac.ir/article-1-59-en.html


Volume 3, Issue 1 (October 2017) Back to browse issues page
International Journal of Research in Applied and Basic Medical Sciences
Persian site map - English site map - Created in 0.07 seconds with 30 queries by YEKTAWEB 3755