The Association of Vitamin D Deficiency with COVID- 19 Severity and Mortality

Samimagham, HamidReza; Hassaniazad, Mehdi; Arabi, Mohsen; Hooshyar, Dariush; Abbasi, Mohammad Amin; Abbasi, Tooba; KazemiJahromi, Mitra

doi:10.52547/rabms.7.4.228

Volume 7, Issue 4 (12-2021) Journal of Research in Applied and Basic Medical Sciences 2021, 7(4): 228-235 | Back to browse issues page

‎ 10.52547/rabms.7.4.228

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Samimagham H, Hassaniazad M, Arabi M, Hooshyar D, Abbasi M A, Abbasi T et al . The Association of Vitamin D Deficiency with COVID- 19 Severity and Mortality. Journal of Research in Applied and Basic Medical Sciences 2021; 7 (4) :228-235
URL: http://ijrabms.umsu.ac.ir/article-1-156-en.html

The Association of Vitamin D Deficiency with COVID- 19 Severity and Mortality

HamidReza Samimagham

, Mehdi Hassaniazad

, Mohsen Arabi

, Dariush Hooshyar

, Mohammad Amin Abbasi

, Tooba Abbasi

, Mitra KazemiJahromi ^*

Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran , mitra.kazemijahromi@gmail.com

Abstract: (1427 Views)

Background & Aims: There are few studies showing the association between vitamin D deficiency and COVID-19 severity and mortality. This study designed to investigate the relationship between vitamin D deficiency and the severity and mortality of COVID-19.
Materials & Methods: The present cross-sectional study was conducted on 48 COVID-19 patients with positive PCR test results. Patients were divided into three groups according to their serum 25-OH vitamin D3 levels: group 1 <20 ng/mL, group 2. 20-50 ng/mL, and group 3, ≥50 ng/ml. The relationship of the levels of vitamin D3, as well as the history of diabetes, hypertension, Ischemic Heart Disease (IHD), Glomerular Filtration Rate (GFR) ≤60 mL/min, LDH ≥500 U/L, and Lymphocyte count ≤1500 with the severity of the disease and its mortality were investigated.
Results: A significant relationship was observed between vitamin D ≤20 ng/mL and the severity (P<0.001) and mortality (P=0.001, adjusted OR=2.4) of the disease in COVID-19 patients. It was also shown that GFR ≤60 mL/min (P=0.02, adjusted OR=3.6), IHD (P=0.04, adjusted OR=2.8), LDH ≥500 U/L (P=0.027, adjusted OR=1.8), and lymphocyte count ≤1500 (P=0.002, adjusted OR=2.2) significantly affected the mortality.
Conclusion: The present study showed a significant relationship between vitamin D deficiency and the severity of the disease and mortality in COVID-19 patients. These results suggest the need for appropriate health policies during the COVID-19 pandemic.

Keywords: itamin D deficiency, COVID 19, mortality

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Type of Study: orginal article | Subject: General

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