Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study

Ansari, Hamid; Ansari, Mohammad Faizan; Gupta, Smrity; Das, Medha

doi:10.52547/rabms.8.2.64

Volume 8, Issue 2 (5-2022) Journal of Research in Applied and Basic Medical Sciences 2022, 8(2): 64-68 | Back to browse issues page

‎ 10.52547/rabms.8.2.64

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Ansari H, Ansari M F, Gupta S, Das M. Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study. Journal of Research in Applied and Basic Medical Sciences 2022; 8 (2) :64-68
URL: http://ijrabms.umsu.ac.ir/article-1-188-en.html

Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study

Hamid Ansari ^*

, Mohammad Faizan Ansari

, Smrity Gupta

, Medha Das

Associate Professor, Rama Medical College & Research Centre, Kanpur,UP,India , hamidansari78@gmail.com

Abstract: (1234 Views)

Background & Aims: The placenta has been described as the most accurate record of the infant’s prenatal experience. The present study was a quantitative study and it was carried out to see the effect of pre-eclampsia on histopathology of placenta and the comparative changes in placenta of preeclamptic patients taking antihypertensives.
Materials & Methods: A total of 60 patients were selected from the Obstetrics and Gynecology Department of Jawahar Lal Nehru Medical College & Hospital, AMU, Aligarh, UP, India and were grouped into control, untreated, and treated groups. Placenta of each group was fixed in 10% formalin solution and processed for section cutting. 5-micron thick sections were prepared and stained with Hematoxylin-eosin and Wiegerts & Van gieson stain and observed under the light of the microscope. A total of 200villi/hpf was counted and percentages for each parameter were expressed.
Result: It has been shown that there was a significant reduction (<0.05) in the percentage of placental villi showing syncytial knot, cytotrophoblast proliferation, Basement membrane thickening, fibrinoid necrosis, and stromal fibrosis.
Conclusion: It has been concluded that antihypertensive drugs were not only effective in controlling the symptoms of pre-eclampsia but also effective in minimizing the placental histopathology and helpful in continuation of pregnancy under low utero-placental flow without completely normalizing the placental changes.

Keywords: Pre-eclampsia, Methyldopa, Chorionic villi, Basement membrane

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Type of Study: orginal article | Subject: General

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