Evaluation of Amoxicillin-Lactose Incompatibility Reactions at the Solid-State Using Physicochemical Methods

Ghaderi, Faranak; Jahangiri, Azin; Fatemi Rad, Saeed

doi:10.61882/rabms.11.3.290

Volume 11, Issue 3 (8-2025) Journal of Research in Applied and Basic Medical Sciences 2025, 11(3): 290-294 | Back to browse issues page

‎ 10.61882/rabms.11.3.290

Ethics code: (IR.UMSU.REC.1397.269)

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Ghaderi F, Jahangiri A, Fatemi Rad S. Evaluation of Amoxicillin-Lactose Incompatibility Reactions at the Solid-State Using Physicochemical Methods. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (3) :290-294
URL: http://ijrabms.umsu.ac.ir/article-1-436-en.html

Evaluation of Amoxicillin-Lactose Incompatibility Reactions at the Solid-State Using Physicochemical Methods

Faranak Ghaderi ^*

, Azin Jahangiri

, Saeed Fatemi Rad

Department of Pharmaceutical and Food Control, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran & Research Center for Experimental and Applied Pharmaceutical Sciences, Urmia University of Medical Sciences, Urmia, Iran , f.ghaderi1390@gmail.com

Abstract: (119 Views)

Background The evaluation of drug-excipient incompatibility is a crucial step in pre-formulation studies, as drug-excipient interaction can have an impact on drug stability and bioavailability. The right selection of excipients is the key to developing successful drug delivery systems or dosage forms. This study is focused on assessing amoxicillin-lactose incompatibility reactions in the solid state through physicochemical techniques.
Methods The mixture of amoxicillin and lactose was made in a 1:1 mass ratio, added to 20% (w/v) water, and kept in closed vials at 60°C. The direct compression method was utilized to prepare amoxicillin, amoxicillin-lactose, and lactose tablets. The manufactured tablets were stored at a temperature of 60°C. Finally, amoxicillin-lactose incompatibility in the solid state was analyzed by Fourier Transform Infrared and differential scanning calorimetry methods over 4 weeks.
Results Physicochemical methods, including differential scanning calorimetry, Fourier Transform Infrared spectroscopy, and visual observation, confirmed incompatibility between amoxicillin and lactose.
Conclusion It is concluded that using lactose in solid pharmaceutical preparations of amoxicillin will result in compatibility problems.

Keywords: Amoxicillin, Excipient, Incompatibility, Lactose, Physicochemical, Solid

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Type of Study: orginal article | Subject: Other

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