Comparative Impacts of Prolonged Orthostasis and Single Intermittent
Prolonged Orthostasis on the Electroencephalogram in Adult Male
Individuals

Jeremiah Adeniyi, Mayowa; Awosika, Ayoola; Nwamaka Kanikwu, Phoebe

doi:https://doi.org/10.61882/rabms.11.4.328

Volume 11, Issue 4 (11-2025) Journal of Research in Applied and Basic Medical Sciences 2025, 11(4): 328-333 | Back to browse issues page

‎ https://doi.org/10.61882/rabms.11.4.328

Ethics code: ED035-2

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Jeremiah Adeniyi M, Awosika A, Nwamaka Kanikwu P. Comparative Impacts of Prolonged Orthostasis and Single Intermittent Prolonged Orthostasis on the Electroencephalogram in Adult Male Individuals. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (4) :328-333
URL: http://ijrabms.umsu.ac.ir/article-1-446-en.html

Comparative Impacts of Prolonged Orthostasis and Single Intermittent Prolonged Orthostasis on the Electroencephalogram in Adult Male Individuals

Mayowa Jeremiah Adeniyi ^*

, Ayoola Awosika

, Phoebe Nwamaka Kanikwu

Department of Physiology, University of Rwanda, Rwanda , 7jimade@gmail.com

Abstract: (73 Views)

Background Orthostatic syncope is a significant public health concern. The study investigated the comparative effects
of prolonged orthostasis and single intermittent prolonged orthostasis on the electroencephalogram in adult males.
The objectives were to investigate the comparative impacts of prolonged orthostasis and single intermittent prolonged
orthostasis on the alpha wave frequency, beta wave frequency, and alpha/beta ratio.
Methods The study adopted a pre-experimental study design (pre-(baseline) and post-comparison). Forty adult male
individuals were selected through the respondent-driven sampling technique. Measurements were conducted at a
reclining sitting position (baseline). The participants then underwent 20 minutes of orthostasis, followed by a single
intermittent, prolonged orthostatic challenge. Orthostasis was defined as the assumption of upright standing from a
sitting position for 20 minutes, and single intermittent prolonged orthostasis consisted of a 1-minute break between
two consecutive 20-minute orthostasis periods. Electroencephalographic (EEG) recordings were obtained using a
PowerLab 26T, as previously reported. The machine has an in-built hardware filtering (low pass filter of 1-2000Hz)
and software-based filtering (Labtutor). Statistical significance was accepted at p < 0.05.
Results When compared to baseline and intermittent orthostatic sessions, respectively, orthostasis has no significant
decrease (p > 0.05) in alpha wave frequency. However, alpha/beta ratio and beta wave frequency were significantly
lower and higher (p < 0.05) during orthostasis when compared to baseline and intermittent orthostatic sessions,
respectively.
Conclusion The findings of the study suggest that prolonged orthostasis (20 minutes) relatively elicited greater
cortical activation when compared to single intermittent prolonged orthostasis in adult male individuals. Cautions are
advised while subjecting patients to orthostatic tolerance tests.

Keywords: Electroencephalogram, Electroencephalography, Orthostasis, Orthostatic stress, Standing position

Full-Text [PDF 322 kb] (28 Downloads)

Type of Study: orginal article | Subject: Internal Medicine Specialist

References

1. Fisher J, Mekjavic I, Ciuha U. Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity. NPJ Microgravity. 2025;11(1):55. doi: 10.1038/s41526-025-00516-6 [DOI:10.1038/s41526-025-00516-6] [PMID] [PMCID]

2. Chu B, Marwaha K, Sanvictores T. Physiology, Stress Reaction.2024. [Google Scholar]

3. Adeniyi M, Fabunmi O, Olaniyan O, Adetunji C, Seriki S. Electroencephalographic findings of young adult males during prolonged unipedal orthostasis. Neuroscience Research Notes. 2023;6(2): 177. Doi: 10.31117/neuroscirn.v6i2.177. [DOI:10.31117/neuroscirn.v6i2.177]

4. Won E , Kim Y. Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. Curr Neuropharmacol. 2016;14(7):665-73. Doi: 10.2174/1570159X14666151208113006. [DOI:10.2174/1570159X14666151208113006] [PMID] [PMCID]

5. Martín-Hernández D, Tendilla-Beltrán H, Madrigal J, García-Bueno B, Leza J, Caso J. Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats. Mol Neurobiol. 2019;56(1):490-501. doi: 10.1007/s12035-018-1096-7. [DOI:10.1007/s12035-018-1096-7] [PMID]

6. Wu Y, Feng W, Chen Q. Impact of scheduled water intake on mild cognitive impairment in patients with orthostatic hypotension. Scientific Reports. 2025;15(1):10269. doi: 10.1038/s41598-025-94818-0. [DOI:10.1038/s41598-025-94818-0] [PMID] [PMCID]

7. Adeniyi M, Fabunmi O, Awosika A. Unraveling the interplay between harmattan wind and baroreflex functions: implications on environmental health and cardiovascular pathophysiology. Exploration Medicine. 2024;5(5):584-600. Doi: 10.37349/emed.2024.00242. [DOI:10.37349/emed.2024.00242]

8. Bustamante-Sánchez Á, Tornero-Aguilera JF, Fernández-Elías VE, Hormeño-Holgado AJ, Dalamitros AA, Clemente-Suárez VJ. Effect of Stress on Autonomic and Cardiovascular Systems in Military Population: A Systematic Review. Cardiol Res Pract. 2020:7986249. doi: 10.1155/2020/7986249. [DOI:10.1155/2020/7986249] [PMID] [PMCID]

9. Adeniyi MJ, Adamu AA, Awosika A. Electroencephalogram of normotensive individuals during sitting and standing blood pressure measurement positions. Cureus. 2024; 16(10):e72154. doi: 10.7759/cureus.72154. [DOI:10.7759/cureus.72154]

10. Barrett K, Susan M, Barman S, Heddwen L. Ganong's Review of Medical Physiology. 23rd edition. New York: MC graw Hills; 2010. [URL]

11. Gantt M, Dadds S, Burns D, Glaser D, Moore A. The Effect of Binaural Beat Technology on the Cardiovascular Stress Response in Military Service Members with Postdeployment Stress. J Nurs Scholarsh. 2017;49(4):411-20. doi: 10.1111/jnu.12304. [DOI:10.1111/jnu.12304] [PMID]

12. Clemente-Suarez V, Palomera P, Robles-Pérez J. Psychophysiological response to acute-high-stress combat situations in professional soldiers. Stress Health. 2018;34(2):247-252. doi: 10.1002/smi.2778. [DOI:10.1002/smi.2778] [PMID]

13. Eoh H, Chung M, Kim SH. Electroencephalographic study of drowsiness in simulated driving with sleep deprivation. International Journal of Industrial Ergonomics. 2005;35(4):307-20. doi: 10.1016/j.ergon.2004.09.006. [DOI:10.1016/j.ergon.2004.09.006]

14. Grenon S, Xiao X, Hurwitz S, Sheynberg N, Kim C, Seely E, et al. Why is orthostatic tolerance lower in women than in men? Renal and cardiovascular responses to simulated microgravity and the role of midodrine. J Investig Med. 2006;54(4):180-90. doi:10.2310/6650.2006.05064 [DOI:10.2310/6650.2006.05064] [PMID]

15. Maeda E, Iwata T, Murata K. Effects of work stress and home stress on autonomic nervous function in Japanese male workers. Ind Health. 2015;53(2):132-8. doi: 10.2486/indhealth.2014-0157. [DOI:10.2486/indhealth.2014-0157] [PMID] [PMCID]

16. Zeigler ZS, Mullane SL, Crespo NC, Buman MP, Gaesser GA. Effects of Standing and Light-Intensity Activity on Ambulatory Blood Pressure. Med Sci Sports Exerc. 2016;48(2):175-81. doi: 10.1249/MSS.0000000000000754. [DOI:10.1249/MSS.0000000000000754] [PMID]

17. Bates LC, Alansare A, Gibbs BB, Hanson ED, Stoner L. Effects of Acute Prolonged Sitting and Interrupting Prolonged Sitting on Heart Rate Variability and Heart Rate in Adults: A Meta-Analysis. Front Physiol. 2021;12:664628. doi:10.3389/fphys.2021.664628. [DOI:10.3389/fphys.2021.664628] [PMID] [PMCID]

18. Barone G, Muldoon M, Conroy M, Paley J, Shimbo D, Perera S. Influence of Recent Standing, Moving, or Sitting on Daytime Ambulatory Blood Pressure. J Am Heart Assoc. 2023; 12(17):e029999. doi: 10.1161/JAHA.123.029999. [DOI:10.1161/JAHA.123.029999] [PMID] [PMCID]

19. Caldwell JA, Prazinko BF, Hall KK. The effects of body posture on resting electroencephalographic activity in sleep-deprived subjects. Clin Neurophysiol. 2000;111(3):464-70. doi: 10.1016/S1388-2457(99)00289-8. [DOI:10.1016/S1388-2457(99)00289-8] [PMID]

20. Caldwell J, Prazinko B, Caldwell J. Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleep-deprived subjects. Clin Neurophysiol. 2003; 114(1):23-31. doi: 10.1016/S1388-2457(02)00283-3. [DOI:10.1016/S1388-2457(02)00283-3] [PMID]

21. Adeniyi M, Awosika A. Impact of Gender on Post-Exercise Orthostasis Related Changes in EEG Amplitudes. Middle East Res J. Med. Sci. 2023;3(1):1-8. doi: 10.36348/merjms.2023.v03i01.001 [DOI:10.36348/merjms.2023.v03i01.001]

22. Adeniyi M, Awosika A, Idaguko A. Impact of Sudden Sit-Stand Postural Switch on Electroencephalogram. Middle East Res J. Med. Sci. 2024;4(1):25-30. doi: 10.36348/merjms.2024.v04i01.005. [DOI:10.36348/merjms.2024.v04i01.005]

23. Adeniyi M, Awosika A, Adamu AA. Relationship between Orthostatic Cardiovascular Responses and Anthropometric Indices in Apparently Healthy Young Female Adults. Cureus. 2025;17(4):e81569. doi: 10.7759/cureus.81569. [DOI:10.7759/cureus.81569]

24. Stemplewski R, Ciążyńska J, Cyma-Wejchenig M. The effect of sleep deprivation on postural stability among physically active young adults. Sci Rep. 2023;13(1):17477 . doi: 10.1038/s41598-023-44790-4. [DOI:10.1038/s41598-023-44790-4] [PMID] [PMCID]

25. Chalmers T, Maharaj S, Lees T, Lin C, Newton P, Clifton-Bligh R, McLachlan C, Gustin S, Lal S. Impact of acute stress on cortical electrical activity and cardiac autonomic coupling. J Integr Neurosci. 2020;19(2):239-48. doi: 10.31083/j.jin.2020.02.74. [DOI:10.31083/j.jin.2020.02.74] [PMID]

26. Lampert R, Tuit K, Hong K, Donovan T, Lee F, Sinha R. Cumulative stress and autonomic dysregulation in a community sample. Stress. 2016;19(3):269-79. doi:10.1080/10253890.2016.1174847. [DOI:10.1080/10253890.2016.1174847] [PMID] [PMCID]

27. Jung J, Cho H, Kang C. Brain activity during a working memory task in different postures: an EEG study. Ergonomics. 2020;63(11):1359-70. doi: 10.1080/00140139.2020.1784467. [DOI:10.1080/00140139.2020.1784467] [PMID]

28. Kahya M, Gouskova N, Lo O, Zhou J, Cappon D, Finnerty E, et al. Brain activity during dual-task standing in older adults. J Neuroeng Rehabil. 2022;19(1)123. doi: 10.1186/s12984-022-01095-3. [DOI:10.1186/s12984-022-01095-3] [PMID] [PMCID]

29. Adeniyi SJ, Idaguko AC. Electroencephalogram of Young Healthy Individuals during and After Seated Rotatory Chair Activity. J of Clin Case Stu, Reviews & Reports. 2024;2(6):1-4. [URL]

30. Mellingsæter MR, Wyller TB, Ranhoff AH, Wyller VB.Fit elderly men can also stand: orthostatic tolerance and autonomic cardiovascular control in elderly endurance athletes. Aging Clin Exp Res. 2015;27(4):499-505.doi: 10.1007/s40520-014-0303-2. [DOI:10.1007/s40520-014-0303-2] [PMID]

31. Ma JR, Fan MM, Wang ZS. Age, preoperative higher serum cortisol levels, and lower serum acetylcholine levels predict delirium after percutaneous coronary intervention in acute coronary syndrome patients accompanied with renal dysfunction. Indian Journal of Psychiatry. 2020;62(2):172-77.doi: 10.4103/psychiatry.IndianJPsychiatry_37_19 [DOI:10.4103/psychiatry.IndianJPsychiatry_37_19] [PMID] [PMCID]

32. United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2019. [URL]