:: Volume 5, Issue 1 (February 2019) ::
RABMS 2019, 5(1): 30-35 Back to browse issues page
Comparison of myocardial apoptosis in 21 and 90 days after birth in pups induced by maternal long term ethanol consumption
Alireza Shirpoor Prof , Faride Nezami Majd Mrs , REZA Gaderi Mr, Roya Naderi Dr
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , r_naderi_s@yahoo.com
Abstract:   (169 Views)
Background & Aims: This study was designed to assess and the cardiac apoptosis after the prenatal and early postnatal ethanol treatment in pups.
Materials and Methods: Pregnant Wistar rats treated with ethanol 4.5g/kg BW once per day from the seventh day of gestation (GD7) throughout lactation. Apoptotic cells, body wight, heart weight and their association on postnatal day 21 (PN-21) and postnatal day 90 (PN-90) was evaluated in male pups.
Results: The results showed that maternal ethanol consumption increased apoptotic cells, decreased heart weight, body weight, and HW/BW after 21 and 90 days of birth compared with the controls. It has found more apoptotic cells in 90 days after births compared with 21 days of age.
Conclusions: our ļ¬ndings revealed that maternal ethanol intake in pups decreased HW/BW ratio in part through apoptosis, which is more predominant in 90 days of age.
Keywords: Ethanol, Offspring, Apoptosis, Heart
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Type of Study: orginal article | Subject: General


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Volume 5, Issue 1 (February 2019) Back to browse issues page