We are thrilled to announce the release of the latest edition of the RABMS Journal Newsletter, where we bring you exciting updates, groundbreaking research, and valuable insights:
Assessment of immune response in ICU admitted SARS-CoV-2 patients from Kashmir, North India
The study examined lymphocyte subpopulations in ICU-admitted COVID-19 patients to understand immune dysregulation. It found increased NLR, T-cell activation, T-cytotoxic exhaustion, and reduced B cells as markers of disease severity and poor outcomes.
The CD4 cell level as a predictive factor for the outcome severity and prognosis of patients with COVID-19
The study examined the link between CD4+ T-cell levels and COVID-19 severity, finding that lower CD4 counts are strongly associated with worse prognosis. The correlation with higher CRP suggests CD4 depletion as a key marker for predicting outcomes, highlighting its potential role in managing severe cases.
Advancements in MRI radiomics for hepatocellular carcinoma: a narrative review
Hepatocellular carcinoma (HCC) is a major global health concern with limited preoperative diagnostic tools. MRI radiomics offers a noninvasive approach to predict outcomes and aid personalized treatment decisions. Further research is needed for its clinical integration in HCC management.
Biochemical and histological assessment of the hepatoprotective effects of Bryophyllum pinnatum leaf extract in Ketamine-induced liver toxicity in male Wistar rats
This study explored the hepatoprotective effects of Bryophyllum pinnatum against ketamine-induced liver toxicity in Wistar rats. The extract demonstrated promising benefits by normalizing liver biomarkers and promoting histological recovery, suggesting its potential for therapeutic use in liver disorders and warranting further research.
Cardiovascular diseases and ischemic stroke: the importance of embolism and thrombosis
This study highlights CHF as an independent risk factor for AIS and emphasizes the clinical significance of monitoring immunological processes over RBC count and HCT levels. Key factors like age, RBC count, anemia, cholesterol, lipoproteins, and blood glucose may aid in differentiating thrombotic and embolic strokes in AIS patients with CHF.
Aphrodisiac activity of ethanolic root extracts of Acacia pycnantha (Golden Wattle) in healthy male Wistar rats
This study investigates the aphrodisiac effects of Acacia pycnantha in male Wistar rats, revealing its ability to enhance sexual behavior, elevate serum-free testosterone levels, and increase serum calcium concentrations, highlighting its potential as a natural aphrodisiac.
Secondary osteoarthritis due to alkaptonuria: a case report
Alkaptonuria is a rare genetic disorder caused by homogentisate 1,2-dioxygenase deficiency, leading to homogentisic acid accumulation. It manifests as homogentisic aciduria, ochronosis, and progressive arthritis, often causing secondary osteoarthritis. Early diagnosis and a multidisciplinary approach are essential for reducing morbidity and improving quality of life.
Molecular surveillance of artemisinin resistance-linked PFK13 gene polymorphisms in Adamawa State, Nigeria
This study investigated Plasmodium falciparum artemisinin resistance by analyzing Pfk13 polymorphisms in clinical isolates from Adamawa State, Nigeria. The absence of Pfk13 mutations suggests parasite sensitivity to artemisinin, though the detected A578S mutation requires further study. Ongoing surveillance is essential to monitor and prevent drug resistance.
Oxidative stress pattern of patients with abnormal thyroid function in Southern Nigeria
This study evaluated antioxidants and oxidative stress in individuals with abnormal thyroid hormone levels in Irrua, Edo State. The results indicate that hyperthyroidism induces oxidative stress, potentially contributing to disease development and other related conditions, regardless of gender.
Prevalence and factors associated with vaccine hesitancy for the booster dose of COVID-19 among undergraduate medical students in Puducherry: a cross-sectional study
This study assessed vaccine hesitancy for the COVID-19 booster dose among undergraduate medical students in Puducherry, identifying socio-demographic, experiential, and perceptual factors as key influences. Addressing these through targeted education, clear communication, and support at vaccination sites can enhance vaccine uptake and help control the pandemic. Further research on diverse populations is needed to evaluate the effectiveness of these strategies.
Electrophysiological analysis of the upward and downward phases of squat and lying leg raise work-out
This study examined the effects of the upward and downward phases of squats and lying leg raises on electroencephalograms (EEG) and electrocardiograms (ECG) in healthy male individuals. It found that the downward phase of squats resulted in higher beta wave frequency, lower alpha wave frequency, and greater cortical activation compared to the downward phase of lying leg raises, providing insights into how different exercises affect brain activity.
A retrospective study of serous ovarian tumour with IHC correlation: a three-year study
This retrospective study analyzed the clinicopathological features of serous ovarian tumors and their correlation with immunohistochemical (IHC) markers to enhance diagnostic accuracy. It found that factors like increasing age, postmenopausal status, bilaterality, and complex morphology were linked to malignancy, and highlighted the importance of IHC markers such as WT1, CK7, CK20, CEA, and CA125 in diagnosing and differentiating these tumors.
Assessment of immune response in ICU admitted SARS-CoV-2 patients from Kashmir, North India
The study examined lymphocyte subpopulations in ICU-admitted COVID-19 patients to understand immune dysregulation. It found increased NLR, T-cell activation, T-cytotoxic exhaustion, and reduced B cells as markers of disease severity and poor outcomes.
The CD4 cell level as a predictive factor for the outcome severity and prognosis of patients with COVID-19
The study examined the link between CD4+ T-cell levels and COVID-19 severity, finding that lower CD4 counts are strongly associated with worse prognosis. The correlation with higher CRP suggests CD4 depletion as a key marker for predicting outcomes, highlighting its potential role in managing severe cases.
Advancements in MRI radiomics for hepatocellular carcinoma: a narrative review
Hepatocellular carcinoma (HCC) is a major global health concern with limited preoperative diagnostic tools. MRI radiomics offers a noninvasive approach to predict outcomes and aid personalized treatment decisions. Further research is needed for its clinical integration in HCC management.
Biochemical and histological assessment of the hepatoprotective effects of Bryophyllum pinnatum leaf extract in Ketamine-induced liver toxicity in male Wistar rats
This study explored the hepatoprotective effects of Bryophyllum pinnatum against ketamine-induced liver toxicity in Wistar rats. The extract demonstrated promising benefits by normalizing liver biomarkers and promoting histological recovery, suggesting its potential for therapeutic use in liver disorders and warranting further research.
Cardiovascular diseases and ischemic stroke: the importance of embolism and thrombosis
This study highlights CHF as an independent risk factor for AIS and emphasizes the clinical significance of monitoring immunological processes over RBC count and HCT levels. Key factors like age, RBC count, anemia, cholesterol, lipoproteins, and blood glucose may aid in differentiating thrombotic and embolic strokes in AIS patients with CHF.
Aphrodisiac activity of ethanolic root extracts of Acacia pycnantha (Golden Wattle) in healthy male Wistar rats
This study investigates the aphrodisiac effects of Acacia pycnantha in male Wistar rats, revealing its ability to enhance sexual behavior, elevate serum-free testosterone levels, and increase serum calcium concentrations, highlighting its potential as a natural aphrodisiac.
Secondary osteoarthritis due to alkaptonuria: a case report
Alkaptonuria is a rare genetic disorder caused by homogentisate 1,2-dioxygenase deficiency, leading to homogentisic acid accumulation. It manifests as homogentisic aciduria, ochronosis, and progressive arthritis, often causing secondary osteoarthritis. Early diagnosis and a multidisciplinary approach are essential for reducing morbidity and improving quality of life.
Molecular surveillance of artemisinin resistance-linked PFK13 gene polymorphisms in Adamawa State, Nigeria
This study investigated Plasmodium falciparum artemisinin resistance by analyzing Pfk13 polymorphisms in clinical isolates from Adamawa State, Nigeria. The absence of Pfk13 mutations suggests parasite sensitivity to artemisinin, though the detected A578S mutation requires further study. Ongoing surveillance is essential to monitor and prevent drug resistance.
Oxidative stress pattern of patients with abnormal thyroid function in Southern Nigeria
This study evaluated antioxidants and oxidative stress in individuals with abnormal thyroid hormone levels in Irrua, Edo State. The results indicate that hyperthyroidism induces oxidative stress, potentially contributing to disease development and other related conditions, regardless of gender.
Prevalence and factors associated with vaccine hesitancy for the booster dose of COVID-19 among undergraduate medical students in Puducherry: a cross-sectional study
This study assessed vaccine hesitancy for the COVID-19 booster dose among undergraduate medical students in Puducherry, identifying socio-demographic, experiential, and perceptual factors as key influences. Addressing these through targeted education, clear communication, and support at vaccination sites can enhance vaccine uptake and help control the pandemic. Further research on diverse populations is needed to evaluate the effectiveness of these strategies.
Electrophysiological analysis of the upward and downward phases of squat and lying leg raise work-out
This study examined the effects of the upward and downward phases of squats and lying leg raises on electroencephalograms (EEG) and electrocardiograms (ECG) in healthy male individuals. It found that the downward phase of squats resulted in higher beta wave frequency, lower alpha wave frequency, and greater cortical activation compared to the downward phase of lying leg raises, providing insights into how different exercises affect brain activity.
A retrospective study of serous ovarian tumour with IHC correlation: a three-year study
This retrospective study analyzed the clinicopathological features of serous ovarian tumors and their correlation with immunohistochemical (IHC) markers to enhance diagnostic accuracy. It found that factors like increasing age, postmenopausal status, bilaterality, and complex morphology were linked to malignancy, and highlighted the importance of IHC markers such as WT1, CK7, CK20, CEA, and CA125 in diagnosing and differentiating these tumors.
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