Journal of Research in Applied and Basic Medical Sciences
Journal of Research in Applied and Basic Medical Sciences
Medical Sciences
http://ijrabms.umsu.ac.ir
1
admin
2717-0098
8
10.61186/rabms
14
8888
13
en
jalali
1399
3
1
gregorian
2020
6
1
6
3
online
1
fulltext
en
Serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I multiple myeloma
Serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I multiple myeloma
تخصصي
Special
پژوهشي
orginal article
<strong><em>Background & Aims</em></strong>: Multiple myeloma (MM) is a type of plasma cell malformation accounting for 10% of the blood cancers with unknown ethiopathology. MM causes changes in inflammatory proteins. The aim of this study was to evaluate the serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I MM<span dir="RTL">.</span><br>
<strong>Materials & Methods:</strong> This case-control study was performed on 28 patients with stage I MM including 14 males and 14 females with mean age of 62.11 ± 6.71 years and 40 individuals as controls including 20 males and 20 females with mean age of 60.25 ± 4.81 years matched in both age and sex. Serum concentrations of inflammatory factors including IL-6, TNF-α and YKL-40 were measured using the sandwich Enzyme Linked Immunosorbent Assay (ELISA) method and the data were analyzed using SPSS software.<br>
<strong>Results</strong>: The serum levels of IL-6 in patients with stage I MM (7.42±5.89 pg/ml) were significantly higher compared to the control group (1.67±1.08 pg/ml); (p< 0.0001). Also, the serum levels of YKL-40 in the patients (45.86 ± 9.14 ng/ml) were significantly higher compared to the control group (35.87 ± 11.2 ng/ml); (p <0.0001). Also, the levels of TNF-α (8.02±1.75 pg/ml) were slightly high compared to the control group (7.77 ± 1.91 pg/ml); (p=0.419).<br>
<strong>Conclusion:</strong> According to the results in MM, inflammatory proteins such as YKL-40 andIL-6 are the major growth factor of the myeloma cells and help their survival.
Multiple myeloma, IL-6, TNF-α, YKL-40
160
166
http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-101-13&slc_lang=en&sid=1
Zeinab
Esmaeilzadeh
monavvar03@gmail.com
1003194753284600874
1003194753284600874
No
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Fatemeh
Kheradmand
kheradmand.f@umsu.ac.ir
1003194753284600875
1003194753284600875
No
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Yousef
Rasmi
rasmiy@umsu.ac.ir
1003194753284600876
1003194753284600876
No
Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
Mohammad Hassan
Khadem-Ansari
mhansari1@gmail.com
1003194753284600877
1003194753284600877
Yes
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran