en Protective Effect of Crocin on Ovarian Ischemia-Reperfusion Injury in Rats تخصصي Special پژوهشي orginal article <strong><em>Background & Aims</em></strong>: Ischemia-reperfusion (I-R) injury of the ovary may lead to ovarian injury. In this study, we investigated the protective effect of the crocin on ovarian I-R injury.<br> <strong><em>Materials & Methods</em></strong><strong>:</strong> Thirty-six male Sprague-Dawley rats were divided into 6 groups: sham surgery, ischemia, I-R, I-R+normal saline (NS), I-R+low dose crocin (20 mg/kg crocin), and I-R+ high dose crocin (80 mg/kg crocin). Neurological function, biochemical and histological evaluation was done 72 hours after ischemia.<br> <strong><em>Results:</em></strong> The plasma levels of malondialdehyde (MDA) and Total Antioxidative Capacity (TAC) in the ischemia, I-R, and I-R+ NS groups increased and decreased significantly compared to the crocin groups, respectively (p<0.01, p<0.05, respectively). Catalase activity in the high dose crocin group was higher than the ischemia, I-R, and I-R+ NS groups (p<0.01). The mean scores of edema, congestion, hemorrhage, and follicular degeneration were significantly lower than in the crocin groups than in the ischemia, I-R, and I-R+NS groups (p<0.05).<br> <strong><em>Conclusion:</em></strong> Findings suggest that crocin may protect ovary from ischemia-reperfusion injury. Crocin, Ischemia, Reperfusion, Ovary, Rat 199 206 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-120-2&slc_lang=en&sid=1 Masumeh Mohammadpour sh11fm@hotmail.com 1003194753284600916 1003194753284600916 No Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran Gholam Hossein Farjah Farjah.GH@umsu.ac.ir 1003194753284600917 1003194753284600917 Yes Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran