Journal of Research in Applied and Basic Medical Sciences

en The Association of Vitamin D Deficiency with COVID- 19 Severity and Mortality The Association of Vitamin D Deficiency with COVID- 19 Severity and Mortality عمومى General پژوهشي orginal article Background & Aims: There are few studies showing the association between vitamin D deficiency and COVID-19 severity and mortality. This study designed to investigate the relationship between vitamin D deficiency and the severity and mortality of COVID-19. Materials & Methods: The present cross-sectional study was conducted on 48 COVID-19 patients with positive PCR test results. Patients were divided into three groups according to their serum 25-OH vitamin D3 levels: group 1 <20 ng/mL, group 2. 20-50 ng/mL, and group 3, ≥50 ng/ml. The relationship of the levels of vitamin D3, as well as the history of diabetes, hypertension, Ischemic Heart Disease (IHD), Glomerular Filtration Rate (GFR) ≤60 mL/min, LDH ≥500 U/L, and Lymphocyte count ≤1500 with the severity of the disease and its mortality were investigated. Results: A significant relationship was observed between vitamin D ≤20 <a name="_Hlk44621960">ng/mL</a> and the severity (P<0.001) and mortality (P=0.001, adjusted OR=2.4) of the disease in COVID-19 patients. It was also shown that GFR ≤60 mL/min (P=0.02, adjusted OR=3.6), IHD (P=0.04, adjusted OR=2.8), LDH ≥500 U/L (P=0.027, adjusted OR=1.8), and lymphocyte count ≤1500 (P=0.002, adjusted OR=2.2) significantly affected the mortality. Conclusion: The present study showed a significant relationship between vitamin D deficiency and the severity of the disease and mortality in COVID-19 patients. These results suggest the need for appropriate health policies during the COVID-19 pandemic. itamin D deficiency, COVID 19, mortality 228 235 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-152-1&slc_lang=en&sid=1 HamidReza Samimagham samimagham@yahoo.com 10031947532846001306 10031947532846001306 No Clinical Research Development Center, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Mehdi Hassaniazad mehdihassaniazad@gmail.com 10031947532846001307 10031947532846001307 No Infectious and Tropical Diseases Research Center,Hormozgan Health Institue,Hormozgan University of Medical Sciences, Bandar Abbas, Iran Mohsen Arabi Arabi.m@iums.ac.ir 10031947532846001308 10031947532846001308 No Department of Internal Medicine and Public Health Research Center, Family Medicine Department, Iran University of Medical Sciences,Tehran, Iran Dariush Hooshyar dariush.hooshyar@gmail.com 10031947532846001309 10031947532846001309 No Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Mohammad Amin Abbasi Amin.abbasi1314@gmail.com 10031947532846001310 10031947532846001310 No Firoozabadi Hospital Clinical Research Development Center,Iran University of Medical Sciences,Tehran, Iran Tooba Abbasi drabbasitooba@gmail.com 10031947532846001311 10031947532846001311 No Department of Pathology, Hormozgan University of Medical Sciences, Bandarabbas, Iran Mitra KazemiJahromi mitra.kazemijahromi@gmail.com 10031947532846001312 10031947532846001312 Yes Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran