en عمومى General كاربردي review article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt">Development of human brain is the essential process in the prenatal period of human growth. </span><span lang="EN" style="font-size:9.0pt">The total surface of human brain area is 1820 cm², and the average cortical thickness is <st1:metricconverter productid="2.7 mm" w:st="on">2.7 mm</st1:metricconverter>. </span><span style="font-size:9.0pt">We reviewed and referred to several articles in this field. Comparative studies of the primate&#39;s brain show that there are general architectural basis governing the brain growth and evolutionary development. In this study, it is discussed about the human brain development with highlighting on the main mechanisms in the embryonic stage and early postnatal life as well as the general architectural values in brain evolution from primates to now. It is suggested that neurodevelopment involves some genetic bases in the neural stem cells proliferation, cortical neurons migration, cerebral cortex folding, synaptogenesis, gliogenesis, and myelination of neural fibers. </span><span style="font-size:9.0pt" lang="EN"></span></span></span></span><br> <br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"></span></span></span></span> Neurodevelopment, Brain Evolution, Prenatal Stage, Primate 137 144 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-197-1&slc_lang=en&sid=1 Fatemeh Tahmasebi fatemetahmasebi4@yahoo.com 10031947532846002635 10031947532846002635 No Department of Anatomy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Homa Rasoolijazi rasooli@yahoo.com 10031947532846002636 10031947532846002636 No Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Shirin Barati baratishirin@yahoo.com 10031947532846002637 10031947532846002637 Yes Department of Anatomy, Saveh University of Medical Sciences, Saveh, Iran