Journal of Research in Applied and Basic Medical Sciences

en The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators تخصصي Special كاربردي review article Leishmaniasis is a neglected disease that affects more than 12 million people worldwide. After parasite inoculum by female blood-sucking insects, e.g. Phlebotomus, neutrophils quickly infiltrate and phagocytes Leishmania parasites. Macrophages are the second immune cells. They possess several pattern recognition receptors that respond to different surface molecules such as Lipophosphoglycan, glycoprotein 63 (GP63), PPG, GIPL, CP, and SAP. It was found that Leishmania GP63 cleaves several targets of infected macrophages, including the myristoylated alanine-rich C kinase substrate, p130CAS, PEST, NF-B, and AP-1. After activation of surface molecules, lipid metabolites of arachidonic acid, including leukotrienes and prostaglandins, are important mediators in Leishmaniasis. These lipid metabolites can be metabolized by different enzymes, including the cyclooxygenase and lipoxygenase. Leishmaniasis, Glycoprotein 63, Surface Molecules 161 168 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-200-1&slc_lang=en&sid=1 Ali Fattahi bafghi a.fattahi@ssu.ac.ir 10031947532846002639 10031947532846002639 Yes Professor, Parasitology and Mycology Department, Infectious Diseases Centers, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Zare fatemezare91@gmail.com 10031947532846002640 10031947532846002640 No Assistant Professor, Reproductive Immunology Research, Sadoughi University of Medical Sciences, Yazd, Iran Mostafa Gholamrezaei m.gholamrezaei6970@gmail.com 10031947532846002641 10031947532846002641 No Assistant Professor, Parasitology and Mycology Department, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mahin Ghafourzadeh mgh.1537@yahoo.com 10031947532846002642 10031947532846002642 No PhD student in Veterinary Parasitology Bahonar University of Kerman, Iran