en عمومى General پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Bladder carcinoma is the second common malignancy of the urogenital system. Bladder malignancy encompasses 5.2% of all forms of cancer. According to study, <i>Her2/neu</i> expression can be considered as a prognostic clinical biomarker for bladder cancer. Target therapy using novel and recombinant chemodrugs such as transtuzumab can be applied in <i>Her2/neu</i> positive cases. Current study aimed to evaluate urothelial neoplasms incidence, to assess <i>Her2/neu</i><b> </b>expression, and to compare its expression with prognostic factors.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> The present study is a prospective study conducted in the Department of Pathology, Narayana Medical College and General Hospital, Nellore, India, for a period of 2 years from June 2019 to June 2021. All the urothelial neoplasm cases reported during the study period were included, and <i>Her2/neu</i> immunohistochemistry has been assessed for the cases.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> Among 71 bladder specimens<b>, </b>48 had urothelial carcinomas (54% of high grade and 46% of low grade), and 20 had benign neoplasms. Among high-grade carcinomas, 91% were muscle invasive and among low grade, 55% were non-muscle invasive. Lateral wall is the common site of urothelial carcinoma. The mean age for high-grade carcinomas was 61-70 years, and it was associated with higher grades and stages of the tumor. In high grade and low-grade carcinomas, males outnumbered females. A significant correlation observed between tumor grade and stage. A significant association was found between <i>Her2/neu</i><b> </b>overexpression with the grade and size of the tumor. No association was found between <i>Her2/neu</i><b> </b>expression and age, gender, stage, and invasion.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><span style="font-size:9.0pt">: It is concluded that identifying the expression of <i>Her2/neu</i> in urothelial carcinoma can help identify eligible candidates for targeted therapy.</span></span></span></span> Transurethral Resection of Bladder Tumor, Hematoxylin, Eosin, Human Epidermal Growth Factor receptor 2 11 23 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-221-1&slc_lang=en&sid=1 Madhulatha Guntimadugu madhulathaguntimadugu@gmail.com 10031947532846002578 10031947532846002578 No Senior Resident, Department of Pathology, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Vijaya Lakshmi Muram Reddy vishmireddy@gmail.com 10031947532846002579 10031947532846002579 Yes Associate Professor, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India Durga Kharidehal drkdurga.path@gmail.com 10031947532846002580 10031947532846002580 No Professor and HOD, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India SyamSundara Rao Byna syam.byna@gmail.com 10031947532846002581 10031947532846002581 No Professor, Department of Pathology, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Mohan Rao Nandam nmr2020kmc@gmail.com 10031947532846002582 10031947532846002582 No Professor, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India Venkata Sunanda Lakshmi Gelli sunandasankar@gmail.com 10031947532846002583 10031947532846002583 No Assistant Professor, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Bhavana Grandhi sashilaboratory@gmail.com 10031947532846002584 10031947532846002584 No Professor, Department of Pathology of Pathology, Aryana medical college and Hospital, Nellore, Andhra Pradesh, India