Journal of Research in Applied and Basic Medical Sciences

en Telfairia occidentalis Hook f. mitigates Carbon Tetrachloride induced Nephrotoxicity in Rat عمومى General پژوهشي orginal article Background & Aims:  Telfairia occidentalis Hook f. is consumed in different parts of the Niger-Delta region of Nigeria due to its high nutritional and medicinal benefits. This study focused on the restorative potentials of Telfaria occidentalis aqueous leaf extract on carbon tetrachloride (CCl4)-induced renal toxicity in wistar rats. Materials & Methods:  In this experimental study, five experimental groups of rats were used. One group received distilled water and serve as normal control. Second group received carbon tetrachloride (CCl4) alone for four days. Third and fourth groups received CCl4 for four days prior to treatment with 200 mg/kg and 400 mg/kg T. occidentalis aqueous extract for six days, respectively. The last group received CCl4 for four days prior to treatment with Silymarin (100 mg/kg) for six days. With exception of normal control rats, all rats received a mixture of freshly prepared CCl4 in olive oil (1 ml/kg, 1:1 intraperitoneally) for 4 days. Activities of renal markers and lipid profile molecules in serum and histopathogical analysis were assessed. Differences between means of groups were determined by One-way ANOVA using SPSS v.20. The mean differences were compared with the Duncan multiple range test. A probability level of less than 5% (P˂0.05) was considered significant. Results:  Results revealed that CCl4 toxicity caused a significant increase (P < 0.05) in the level of serum kidney function markers (Creatinine and Urea) and in lipid profile molecules (Total Cholesterol and Triglycerides) whereas T. occidentalis administration showed a dose-dependent nephro-protection as it significantly mitigated the effects of CCl4 on the kidney function markers and lipid profile molecules assessed. The observed CCl4 toxicity and renal protection by T. occidentalis were corroborated by the results of histopathological analysis. Conclusion:  The results showed that T. occidentalis aqueous leaf extract mitigated the exacerbated effect of CCl4 on renal functions which can be attributed to its bioactive agents. Carbon Tetrachloride, Kidney, Rats, Telfaria occidentalis 130 137 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-224-2&slc_lang=en&sid=1 Usunomena Usunobun usunobun.usunomena@edouniversity.edu.ng 10031947532846002114 10031947532846002114 Yes Department of Biochemistry, Faculty of Basic Medical Sciences, Edo State University Uzairue, Edo State, Nigeria Augustine Okpiabhele okpiabheleaustin405@gmail.com 10031947532846002115 10031947532846002115 No Department of Biological and Chemical Sciences (Biochemistry Unit), Faculty of Natural and Applied Sciences, Michael and Cecilia Ibru University, Agbarha-Otor, Ughelli, Delta State, Nigeria