Journal of Research in Applied and Basic Medical Sciences

en Effect of prophylactic single dose parenteral amiodarone in mitral valve replacement surgery Other Other پژوهشي orginal article Background & Aims: Amiodarone is a purposive medicine useful in restoring sinus rhythm (SR) after cardiac surgery. The aim of the study was to evaluate the effect of prophylactic intraoperative single-dose intravenous amiodarone and to convert atrial fibrillation (AF) into normal sinus rhythm (NSR) in the patients undergoing valve replacement surgery. Materials & Methods: In this prospective and interventional study, 180 patients of ASA III (American Society of Anesthesiologist) classification between the ages of 18-60 years, posted for Rheumatic Mitral Valve Replacement were allocated randomly to two equal groups (Group-1 and Group-2). Their hemodynamics parameters, Pre and post pulse rate, ECG findings and incidence of AF and VT/VF and ICU, Hospital stay were noted. Data was analysed with SPSS v26 using chi-square test. A two-tailed P value of 0.05 or less was regarded as statistically significant. Results: In our study, we found that there was suggestive significance between both groups as regard to mean pulse rate changes after 5 and 10 minutes of induction (P value >0.05). At the end of surgery, there was developing atrial fibrillation in few patients and sinus rhythm in more (P value >0.05). Postoperative arrhythmias in the first 24 hrs, AF was seen in 9(10%) patients in the Group 1 compare to Group 2 49 (54.4%) (P <0.001). In both groups as regard to Mechanical ventilation & ICU stay was of suggestive significance in amiodarone group (P value <0.0001). Conclusion: The incidence of post-operative AF among high-risk patients was significantly reduced by a prophylactic amiodarone treatment resulting in a shorter time of intensive care unit and hospital stay.   Atrial Fibrillation, Amiodarone, Normal Sinus Rhythm, Valve Surgery 121 129 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-385-1&slc_lang=en&sid=1 Rahul Maria rahulmaria1384@gmail.com 10031947532846002883 10031947532846002883 No Former DM Resident, Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, India Ritesh Shah rbshah76@gmail.com 10031947532846002884 10031947532846002884 Yes Professor, Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, India (Corresponding Author) Himani Pandya himani@unmicrc.org 10031947532846002885 10031947532846002885 No Research Associate, Department of Research, U N Mehta Institute of Cardiology and Research Center, India Arun Kumar medrarun@gmail.com 10031947532846002886 10031947532846002886 No DM Resident, Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, India Ramesh Patel dr.ramesh33@gmail.com 10031947532846002887 10031947532846002887 No Professor and HOD, Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, India