en عمومى General پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span lang="EN-GB" style="font-size:9.0pt">The link between Chronic Kidney Disease (CKD) and Cardio Vascular Disease (CVD) has long been established. Hyperuricemia and inflammatory markers such as hs-CRP are considered to be non-traditional risk factors for cardiovascular risk in CKD patients. The aim of this study was to estimate serum hs-CRP and uric acid levels in patients with chronic kidney disease along with age and sex matched healthy controls and see whether they are statistically significant or not.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><i><span lang="EN-GB" style="font-size:9.0pt">:</span></i></b><span lang="EN-GB" style="font-size:9.0pt"> In this case-control study, totally 30 cases with ages varied from 30-70 years and 30 age and sex matched controls were selected based on inclusion and exclusion criteria. Serum CRP and Uric Acid were analyzed on Beckman Coulter AU-480 fully </span><b><i><span style="font-size:9.0pt">automated</span></i></b><span lang="EN-GB" style="font-size:9.0pt"> analyser, by Turbidimetric end point method and Modified Trinder end point method</span><span style="font-size:9.0pt">,</span><span lang="EN-GB" style="font-size:9.0pt"> respectively. Qualitative data is expressed as proportion and percentage while quantitative data is expressed as mean+SD. Statistical analysis is done using Microsoft Excel sheet and Graph pad software. A <i>p value <0.05</i> is considered as statistically significant. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span lang="EN-GB" style="font-size:9.0pt">Results:</span></i></b><span lang="EN-GB" style="font-size:9.0pt"> Results show that the patients with CKD had higher levels of hs-CRP and Uric Acid than healthy controls, implying a higher risk of cardiovascular disease in this group. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span lang="EN-GB" style="font-size:9.0pt">Conclusion:</span></i></b><b> </b><span lang="EN-GB" style="font-size:9.0pt">The present study implies that regular monitoring of these biomarkers is required in CKD patients, to assess the progression of atherosclerosis and evaluate potential interventions, thereby preventing morbidity & mortality due to cardiovascular disease.</span></span></span></span><span style="font-size:12pt"><span style="background:#d9d9d9"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"></span></span></span></span></span> Chronic Kidney Disease, Serum hs-CRP, Serum Uric Acid 224 232 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-204-3&slc_lang=en&sid=1 Thammisetty Anil Kumar anil.mbbs@yahoo.co.in 10031947532846003132 10031947532846003132 No Associate professor, Department of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, A&N Islands, India Lakshmi Keerthana Badam lakshmikeerthana23@gmail.com 10031947532846003133 10031947532846003133 No Assistant Professor, Department of Biochemistry, Rangaraya Medical College, Kakinada, Andhra Pradesh, India Bhagya Lakshmi Vanapalli biochem2102@gmail.com 10031947532846003134 10031947532846003134 Yes Professor & HOD, Department of Biochemistry, Rangaraya Medical College, Kakinada, Andhra Pradesh, India