en Other Other پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background</span></i></b><span style="font-size:9.0pt"> <b><i>&</i></b> <b><i>Aims</i></b></span><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">&nbsp;One of the most popular Anabolic Androgenic Steroids (AAS) among athletes and teenagers is Nandrolone Decanoate (ND), a synthetic testosterone analog. Chronic AAS consumption raises the risk of cardiovascular problems in athletes, however the mechanism causing such changes is not known. This experimental research aims to investigate the impact of nandrolone decanoate administration on heart in white male albino rats. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods:</span></i></b><span style="font-size:9.0pt"> Twenty male Albino rats, split into two groups, were used in the study. Group A served as a control, getting peanut oil injections, while Group B received decanoate injections at a dose of 10 mg/kg body weight weekly for eight weeks. After the eighth week, the rats were sacrificed under anesthesia in accordance with the recommendations issued by the Ethical Committee. Following sacrifice, the rats were dissected and their tissues processed using normal histology procedures. Sections were stained with hematoxylin and eosin, and microscopic observations were recorded in groups. In order to properly label and analyze the photos, photographic microscopy was used.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> &nbsp;After Eighth week, the control group&#39;s heart showed no obvious changes under microscopic examination, whereas the ND treated group showed intermuscular hemorrhages, congested myocardial vessels, widely separated cardiomyocytes, fragmented muscle fibers, and cardiomyocytes showing vesicular nuclei and few degenerative changes. These results suggest that ND treatment may cause particular cardiac structural changes in white male albino rats.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">&nbsp;The study suggests that Nandrolone abuse can lead to cardiac problems such as severe degeneration, myocardial vascular congestion, and intermuscular hemorrhages. The study emphasizes the significance of investigating the long-term effects of these medications, as well as the importance of well-designed studies and proper dosage considerations.</span></span></span></span><br> <br type="_moz" > &nbsp; Albino Rats, Anabolic Steroids, Heart, Nandrolone Deconate 205 212 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-396-1&slc_lang=en&sid=1 Parvaiz Ahmad Lone parvaizgull01@gmail.com 10031947532846002947 10031947532846002947 Yes Senior Resident, Department of Anatomy, Government Medical College, Anantnag Mudasir Ahmad Khan doctorkhan97@gmail.com 10031947532846002948 0009-0007-6138-3104 No Assistant Professor, Department of Anatomy, Government Medical College, Anantnag Yunis Parveiz Malik dryunismalik@gmail.com 10031947532846002949 10031947532846002949 No Post PG, Department of Anatomy, Government Medical College, Srinagar