en عمومى General پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span lang="EN-IN" style="font-size:9.0pt">Pregnancy is a diabetogenic state characterized by hyperinsulinemia and insulin resistance. The primary goal of identifying </span><span style="font-size:9.0pt">gestational diabetes mellitus (</span><span lang="EN-IN" style="font-size:9.0pt">GDM) is to detect women at risk for adverse perinatal outcomes. Proper diagnosis of this condition and its complications is essential for the benefit of both maternal and child health. The uric acid/HDL-C ratio (UHR), which combines two metabolic parameters</span><span style="font-size:9.0pt">&mdash;</span><span lang="EN-IN" style="font-size:9.0pt">serum uric acid and HDL-C</span><span style="font-size:9.0pt">&mdash;</span><span lang="EN-IN" style="font-size:9.0pt"> is a powerful predictor of metabolic deterioration. </span><span lang="EN-GB" style="font-size:9.0pt">The present study aims to understand the role of metabolic derangement in the development of GDM in pregnant women and to compare these findings with those of healthy controls. The objectives of the study are to compare the serum UHR in the GDM and control populations and to correlate UHR in each group with glycemic status markers and BMI.</span> <span lang="EN-IN" style="font-size:9.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span lang="EN-IN" style="font-size:9.0pt">Based on inclusion and exclusion criteria, a total of 30 cases and 30 age-matched controls were selected for the study. The age range was 18 to 35 years. All serum parameters were analyzed using a Beckman Coulter AU-480 fully automated analyser. UHR was calculated from serum uric acid and HDL-C values using the formula: UHR = UA/HDL-C.</span><b><span style="font-size:9.0pt"></span></b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">The </span><span lang="EN-IN" style="font-size:9.0pt">results show that patients with GDM had higher uric acid levels and UHR and lower HDL-C levels than healthy controls, suggesting significant metabolic derangement in this group. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt">Conclusion:</span></b><span lang="EN-IN" style="font-size:9.0pt"> Routine use of UHR as an early screening tool can help identify metabolic abnormalities in GDM. This will also aid in early pharmacological intervention, thereby preventing future complications for both the mother and foetus.</span><b><span style="font-size:9.0pt"></span></b></span></span></span><span style="font-size:12pt"><span style="background:#d9d9d9"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"></span></span></span></span></span> Hyperinsulinemia, Insulin resistance, Uric acid/HDL-c ratio (UHR) 410 419 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-204-4&slc_lang=en&sid=1 Mohammed Shaguftha Anjum anjum234@gmail.com 10031947532846003596 10031947532846003596 No Final year MBBS, Rangaraya Medical College, Kakinada, Andhra Pradesh, India Lakshmi Keerthana Badam lakshmikeerthanabadam239@gmail.com 10031947532846003597 10031947532846003597 No Assistant Professor, Dept. of Biochemistry, Rangaraya Medical College, Kakinada, Andhra Pradesh, India Vanapalli Bhagya Lakshmi biochem2102@gmail.com 10031947532846003598 10031947532846003598 No Professor & HOD, Dept. of Biochemistry, Rangaraya Medical College, Kakinada, Andhra Pradesh, India Thammisetty Anil Kumar anil.mbbs@yahoo.co.in 10031947532846003599 10031947532846003599 Yes Associate Professor, Dept. of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences (ANIIMS), Sri Vijaya Puram, A&N Islands, India