en Microbiology Microbiology پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Urinary tract infections (UTI) are a leading cause of bacterial infections in humans.The widespread use of antibiotics has resulted in the emergence of antibiotic-resistant microorganisms. Hence, the current study was conducted to investigate the antibiotic sensitivity pattern of uropathogens in UTI.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">A total of 642 urine samples were collected from suspected UTI patients and tested microbiologically. Antimicrobial susceptibility tests were performed for the isolated pathogens using the Kirby- Bauer disk diffusion method. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Out of 642 urine samples, 308 (48%) were found to exhibit significant bacteriuria. Females had a higher rate of UTI (68%) than males (32%), with a higher prevalence in the middle-aged group, while males reported a higher prevalence in the elderly group, which was statistically significant. The most common organism was <i>Escherichia coli</i> (57.2%), followed by <i>Klebsiella pneumoniae</i> (26.3%), <i>Pseudomonas aeruginosa</i> (8.4%), <i>Proteus spp.</i> (3.6%), <i>Enterococcus spp. </i>(2.6%), and <i>Staphylococcus aureus</i> (1.9%). UTI were more common in middle-aged female patients (31 to 45 years), while in males, high prevalence was seen in older patients (>45 years). Meropenem, Gentamicin, Nitrofurantoin, and Co-Trimoxazole were amongst the most sensitive drugs against <i>E.coli</i> and <i>K.pneumoniae</i>.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt">Due to the irrational and injudicious use of antibiotics, commonly isolated uropathogens have a changing resistance pattern, resulting in reduced treatment effectiveness. This could be overcome by routine antimicrobial resistance surveillance, antimicrobial stewardship measures, and culture-guided therapy.</span></span></span></span><span style="font-size:12pt"><span style="background:#d9d9d9"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"></span></b></span></span></span></span> Antibiotic susceptibility pattern, Antimicrobial resistance, Bacteriuria, Escherichia coli, Urinary tract infection, Uropathogens 318 323 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-410-2&slc_lang=en&sid=1 Abhishek Mehta abhishekmehta623@gmail.com 10031947532846003564 10031947532846003564 Yes Associate Professor, Department of Microbiology, Govt. Medical College, Datia (M.P.), India Dharmendra Singh Gurjar doctordharmendrasinghgurjar@gmail.com 10031947532846003565 10031947532846003565 No PG student, Department of Microbiology, Govt. Medical College, Datia(M.P.), India Vijay Singh Rajak jayvi.singh1980@gmail.com 10031947532846003566 10031947532846003566 No PG student, Department of Microbiology, Govt. Medical College, Datia(M.P.), India