en عمومى General پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Serous ovarian tumors account for 40% of all ovarian cancer cases and remain a major cause of cancer-related mortality in women due to late-stage diagnosis. This retrospective study aimed to analyze the clinicopathological features of serous ovarian tumors and their correlation with immunohistochemical (IHC) markers, including WT-1, CA-125, CK-7, CK-20, and CEA, to improve diagnostic accuracy and prognostic evaluation.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Materials & Methods:</span></i></b><span style="font-size:9.0pt"> The study included pathology data from August 2020 to July 2023, focusing on patients with ovarian neoplasms. Clinical characteristics were correlated with IHC markers. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Results:</span></i></b><span style="font-size:9.0pt"> Results showed that 62% of tumors occurred in women of reproductive age, with abdominal pain being the most common symptom (62%). The majority (88%) of tumors were benign, while 8% were malignant and 4% were borderline. Most tumors (88%) were unilateral, and the predominant tumor size ranged from 6 to 10 cm. High-grade serous carcinomas were identified in two cases, exhibiting Ki-67 labeling indices of 26&ndash;50% and >50%, respectively. Ki-67 expression was significantly higher in malignant tumors (50%) compared to borderline tumors (26%) (p < 0.001).</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-size:9.0pt">IHC analysis showed strong WT1 nuclear expression, CK7 cytoplasmic expression, and CA125 membrane staining in serous ovarian cancer cases. CK20 and CEA were negative in all cases of serous adenocarcinoma. Malignant tumors exhibited significantly higher Ki-67 expression than borderline tumors.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Conclusion: </span></i></b><span style="font-size:9.0pt">The study concluded that increasing age, postmenopausal status, bilaterality, and complex tumor morphology were associated with malignancy risk. The use of IHC markers such as WT1, CK7, CK20, CEA, and CA125 remains essential for accurate diagnosis and differentiation of serous ovarian tumors.</span></span></span></span><span style="font-size:12pt"><span style="background:#d9d9d9"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="font-size:9.0pt"></span></b></span></span></span></span> Hysterectomy, Ki-67 labeling, Ovarian tumors, postmenopausal malignancy 115 124 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-269-4&slc_lang=en&sid=1 Manoja Vaddadi vaddadi71@gmail.com 10031947532846003923 10031947532846003923 No Associate Professor, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telengana, India Ali Baqher Hussaini Syed s.alibaqher@gmail.com 10031947532846003924 0009-0003-8573-239X No Consultant Pathologist, S.N Diagnostic Centre, Kalaburagi, Karnataka, India Jyothi V vaddadijyothi@gmail.com 10031947532846003925 10031947532846003925 No Associate professor, Department of Pathology, Government medical College, Nandyal, Andhra Pradesh, India Shamoon Sulthana dr.kshilpa@rediffmail.com 10031947532846003926 10031947532846003926 Yes Assistant Professor, Department of Pathology, Apollo Institute of Medical Science and Research, Jubilee hills, Hyderabad, Telengana, India Florence Nightingale suresh_harithasa@yahoo.com 10031947532846003927 009-0001-0670-4573 No Professor, Department of Pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telengana, India Priyatham Gundla research.nmch1@rediffmail.com 10031947532846003928 10031947532846003928 No Postgraduate, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telengana, India Purnima Sirisha Gattim research.nmch@rediffmail.com 10031947532846003929 10031947532846003929 No Postgraduate, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telengana, India