en Other Other پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">Congestive heart failure (CHF) is a risk factor for acute ischemic stroke (AIS) incidence. Currently, no specific biomarker exists to differentiate thrombotic and embolic strokes. Managing and treating AIS patients with CHF, particularly those with embolic or thrombotic causes, requires a nuanced understanding of CHF&rsquo;s role in AIS.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> In this study, we reevaluated the medical records of patients admitted to Urmia Imam Khomeini Hospital from 2006 to 2023. The data was entered into SPSS IBM 23 and evaluated statistically. The exclusion criterion was incomplete medical records. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">Our results showed that the mean age of AIS patients with and without CHF was 71.18 &plusmn; 13.00 and 66.22 &plusmn; 14.76 years, respectively (<i>p</i> = 0.001). Hemoglobin levels, lymphocyte and neutrophil counts, and white blood cell counts showed a statistically significant difference between AIS patients with and without CHF. The frequency of thrombotic strokes was twice than that of embolic strokes, with the mean ages 68.75 &plusmn; 13.00 and 64.76 &plusmn; 16.38 years, respectively (<i>p</i> < 0.001). Patients with atrial fibrillation had an 8.27-fold increased risk of embolic ischemic stroke compared to those without atrial fibrillation (<i>p</i> < 0.001). Blood glucose, red blood cell count, total cholesterol, and LDLc cholesterol showed significant differences between embolic and thrombotic ischemic stroke patients.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">In conclusion, the findings show that CHF is a risk factor for AIS that acts independently of gender. Monitoring immunological processes may be more clinically significant than RBC count and HCT levels in AIS patients with CHF. Additionally, age, RBC count, anemia, cholesterol, lipoproteins, and blood glucose levels could be used in clinical settings for the differential diagnosis of thrombotic versus embolic ischemic stroke. </span><b><span style="font-size:9.0pt"></span></b></span></span></span><br> <span style="font-size:12pt"><span style="background:#d9d9d9"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"></span></b></span></span></span></span> Congestive heart failure, Embolic, Ischemic stroke, Laboratory findings, Thrombotic 48 58 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-285-2&slc_lang=en&sid=1 Mohammadreza Amirinikpour ghzafar1@yahoo.com 10031947532846003873 10031947532846003873 Yes Department of Neurology, Urmia University of Medical Sciences, Urmia, Iran Ali Zolfi-Gol ghzafar2@yahoo.com 10031947532846003874 10031947532846003874 No Department of Pediatrics Cardiology, Shahid Motahari Hospital, Urmia University of Medical Sciences, Urmia Iran Surena Nazarbaghi ghzafar3@yahoo.com 10031947532846003875 10031947532846003875 No Department of Neurology, Urmia University of Medical Sciences, Urmia, Iran Arash Mosarrezaii ghzafar4@yahoo.com 10031947532846003876 10031947532846003876 No Department of Neurology, Urmia University of Medical Sciences, Urmia, Iran Fatemeh Hamzeh fatemeham@yahoo.com 10031947532846003877 10031947532846003877 No Department of Neurology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran Zafar Gholinejad ghzafar@yahoo.com 10031947532846003878 10031947532846003878 No Department of Medical Laboratory Science, Urmia Branch, Islamic Azad University, Urmia, Iran