Journal of Research in Applied and Basic Medical Sciences

en Oxidative stress pattern of patients with abnormal thyroid function in Southern Nigeria Other Other پژوهشي orginal article Background & Aims: In humans, oxidative changes have been associated with abnormal thyroid hormone levels. The aim of the study was to evaluate antioxidants and oxidative stress parameters in subjects with abnormal thyroid hormones in Irrua, Edo State. Materials & Methods: Two hundred samples were used for this study including 120 test subjects visiting the clinic with abnormal thyroid-related complaints and 80 healthy control groups. The <a name="_Hlk189304587">triiodothyronine (T3), thyroxine (T4)</a>, thyroid stimulating hormone (TSH), malondialdehyde (MDA), reduced glutathione (rGSH), and catalase levels were determined using standard laboratory procedures. The results were presented in tables and charts as mean ± standard deviation. Results: Analysis of oxidative stress markers revealed that MDA levels in test subjects (4.9 ± 0.6) were not significantly different from the control group (4.7 ± 0.5; P = 0.77). Similarly, catalase activity in test subjects (216.9 ± 25.8) showed no significant difference compared to controls (178.6 ± 19.4; P = 0.29). However, rGSH levels were significantly lower in test subjects (74.8 ± 9.7) compared to controls (134.6 ± 9.7; p < 0.001). When analyzing thyroid function parameters, females with normal thyroid function exhibited significantly higher serum catalase levels (283.1 ± 38.9) compared to those with subclinical hyperthyroidism (101.5 ± 8.4) or hyperthyroidism (131.9 ± 13.0; P < 0.05). Among male participants, those with hyperthyroidism showed significantly lower rGSH levels (77.3 ± 23.5) compared to both males with subclinical hypothyroidism (186.0 ± 00.0) and healthy male controls (136.8 ± 7.7; P < 0.05). A key finding from this study is that thyroid dysfunction may not cause oxidative stress through lipid peroxidation. However, by the suppression of rGSH, this can have severe implications on the overall antioxidant defense system of the body predisposing it to oxidative damage and diseases. Conclusion: The findings of this study show that hyperthyroidism induces oxidative stress regardless of gender, which could play a major role in disease formation and other associated abnormal conditions. Catalase, Glutathione, Hormone, Malondialdehyde, Oxidative, Thyroid 85 97 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-456-1&slc_lang=en&sid=1 Oloruntoba Festus festusoloruntoba2018@gmail.com 10031947532846003903 0009-0009-3720-4350 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Ebenezer Dic-Ijiewere ebenexar@gmail.com 10031947532846003904 10031947532846003904 Yes Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Felix Ailemen labheth@gmail.com 10031947532846003905 0009-0009-6826-4241 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Nathaniel Imafidon imafidon32@gmail.com 10031947532846003906 0009-0004-0643-3699 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Joseph Ebo ebojoseph@gmail.com 10031947532846003907 0009-0008-0644-6149 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Chikezie Nwankwo nwankwochikezie@gmail.com 10031947532846003908 0009-0006-2078-9944 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria Friday Iweka iwekafriday@gmail.com 10031947532846003909 10031947532846003909 No Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria