TG: HDL, AST: ALT, A:G Ratios in Alcoholic and Non-alcoholic Fatty Liver patients

Manish, Abhinav; Bharosay, Anuradha; Negi, Kanchan; Srivastava, Ritesh

doi:10.61186/rabms.10.3.279

Volume 10, Issue 3 (7-2024) Journal of Research in Applied and Basic Medical Sciences 2024, 10(3): 279-284 | Back to browse issues page

‎ 10.61186/rabms.10.3.279

Ethics code: GBCM/IEC/2023/07-03

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Manish A, Bharosay A, Negi K, Srivastava R. TG: HDL, AST: ALT, A:G Ratios in Alcoholic and Non-alcoholic Fatty Liver patients. Journal of Research in Applied and Basic Medical Sciences 2024; 10 (3) :279-284
URL: http://ijrabms.umsu.ac.ir/article-1-333-en.html

TG: HDL, AST: ALT, A:G Ratios in Alcoholic and Non-alcoholic Fatty Liver patients

Abhinav Manish

, Anuradha Bharosay ^*

, Kanchan Negi

, Ritesh Srivastava

Professor & H.O.D, Department of Biochemistry, GBCM Jhajra Dehradun Uttarakhand 248007, India , bharosayanuradha@gmail.com

Abstract: (337 Views)

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is typically first suspected when the results of liver function tests, measured as part of routine testing, are abnormal. Most often observed biochemical pattern in hepatic steatosis due to NAFLD is of increased levels of transaminases, with alanine aminotransferase (ALT) levels exceeding those of aspartate aminotransferase (AST). This classical pattern is particularly useful in differentiating between hepatic steatosis from NAFLD.The pathophysiology of non-metabolic complication like atherosclerosis and cardiovascular disease (CVD) depends vastly on fatty acids (lipid) transportation and Deposition. AIM Estimation of the AST: ALT, Albumin: Globulin, and TG: HDL ratios, along with their comparison among the Alcoholic and Non-alcoholic fatty liver disease patient.
Materials & Methods: A prospective observational cohort study was conducted in the department of Biochemistry at GBCM & KKBM Subharti hospital, Jhajra, Dehradun after obtaining the ethical clearance from the institutional ethical committee (IEC) with registration no GBCM/IEC/2023/07-03 dated 25/07/2023. Cases comprised of 120 Ultrasonographically confirmed fatty liver patients by Random sampling method. 5ml blood sample was collected in the serum separation test tube (SST) and results were analysed using SPSS v.20. and statistical p-value of <0.05 was considered to be significant.
Results: Extremely significant difference in TG: HDL and A:G ratio was found between two groups with statistical p-value of <0.05 and <0.01 respectively.
Conclusion: This study can significantly contribute in evaluating the lipid derangements in two groups and their management.

Keywords: Alcoholic fatty liver, AST: ALT ratio, A: G ratio, Fatty Liver, TG: HDL ratio, Non-Alcoholic Fatty Liver

Full-Text [PDF 328 kb] (136 Downloads)

Type of Study: biochemistry | Subject: General

References

1. Ludwig J, Viggiano TR, Mcgill DB, Oh B. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55(7):434-8. [GOOGLE SCHOLAR]

2. LaBrecque DR, Abbas Z, Anania F, Ferenci P, Khan AG, Goh K-L, et al. World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Clin Gastroenterol 2014;48:467-73. [DOI:10.1097/MCG.0000000000000116] [PMID]

3. Araújo AR, Rosso N, Bedogni G, Tiribelli C, Bellentani S. Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future. Liver Int 2018;38:47-51. [DOI:10.1111/liv.13643] [PMID]

4. Chun Jen L. Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese. J Gastroenterol Hepatol 2012;27:1555-60. [DOI:10.1111/j.1440-1746.2012.07222.x] [PMID]

5. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Dig Dis 2010;28:155-61. [DOI:10.1159/000282080] [PMID]

6. Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002;17 Suppl:S186-90. [DOI:10.1046/j.1440-1746.17.s1.10.x]

7. Harrison SA, Kadakia S, Lang KA, Schenker S. Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 2002;97(11):2714-24. [DOI:10.1111/j.1572-0241.2002.07069.x] [PMID]

8. Gofton C, Upendran Y, Zheng MH, George J. MAFLD: How is it different from NAFLD? Clin Mol Hepatol 2023 Feb;29(Suppl):S17-S31. [DOI:10.3350/cmh.2022.0367] [PMID] []

9. Christodoulidis G, Vittorio TJ, Fudim M, Lerakis S, Kosmas CE. Inflammation in coronary artery disease. Cardiol Rev 2014;22:279-288. [DOI:10.1097/CRD.0000000000000006] [PMID]

10. Kosmas CE, Silverio D, Sourlas A, Montan PD, Guzman E, Garcia MJ. Anti-inflammatory therapy for cardiovascular disease. Ann Transl Med. 2019;7:147. [DOI:10.21037/atm.2019.02.34] [PMID] []

11. Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransferase: Potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol 1999;94:1018-22. [DOI:10.1111/j.1572-0241.1999.01006.x] [PMID]

12. Shiha G, Korenjak M, Eskridge W, Casanovas T, Velez-Moller P, Högström S, et al. Redefining fatty liver disease: An international patient perspective. Lancet Gastroenterol Hepatol 2021;6:73-79. [DOI:10.1016/S2468-1253(20)30294-6] [PMID]

13. De Ritis F, Coltorti M, Giusti G. An enzymic test for the diagnosis of viral hepatitis; the transaminase serum activities. Clin Chim Acta 1957;2:70-4. [DOI:10.1016/0009-8981(57)90027-X] [PMID]

14. Kim SG, Kim HY, Seo JA, Lee KW, Oh JH, Kim NH, et al. Relationship between serum adiponectin concentration, pulse wave velocity, and nonalcoholic fatty liver disease. Eur J Endocrinol 2005;152:225-31. [DOI:10.1530/eje.1.01842] [PMID]

15. Sattar N, Forrest E, Preiss D. Non-alcoholic fatty liver disease. BMJ 2014 Jul 29;349:g4596. [DOI:10.1136/bmj.g4596] [PMID] []

16. Arora M, Mahat R, Kumar S. Sharma A, Batra J. Evaluation of AST/ALT Ratio in patients of alcoholic Liver Disease. Bull Pharm Med Sci 2015;vol 3:3027-30. [URL]

17. Nyblom H, Berggren U, Balldin J, Olsson R. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol Alcohol 2004;39(4):336-39. [DOI:10.1093/alcalc/agh074] [PMID]

18. Bayard M, Holt J, Boroughs E. Nonalcoholic fatty liver disease. Am Fam Physician 2006 Jun 1;73(11):1961-8. [PMID]