en Other Other پژوهشي orginal article <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Infertility affects a significant proportion of couples, with male factors contributing to many cases. Diabetes mellitus (DM) is a major risk factor for male infertility, potentially affecting semen quality. To evaluate the impact of type 2 diabetes mellitus on semen parameters in Sudanese males. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">The study included 600 Sudanese men, consisting of 300 individuals diagnosed with type 2 diabetes mellitus (T2DM) and 300 non-diabetic individuals serving as controls. Anthropometric measurements and semen analysis, including semen volume, sperm count, motility, and morphology, were assessed. &nbsp;</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> The mean ages of the diabetic and non-diabetic groups were 35 &plusmn; 1.5 years and 34 &plusmn; 1.7 years, respectively (<i>P</i> = 0.60). Significant differences were observed in body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR). Diabetic patients had a higher BMI (31.5 &plusmn; 0.5 kg/m&sup2;) compared to non-diabetic controls (24.0 &plusmn; 0.3 kg/m&sup2;, <i>P</i> = 0.01). Semen volume was significantly lower in diabetic patients (2.46 &plusmn; 1.18 mL) than in non-diabetic controls (2.75 &plusmn; 1.19 mL, <i>P</i> = 0.047). Sperm count showed no significant difference (67.3 &plusmn; 33.1 million/mL in diabetics vs. 68.3 &plusmn; 40 million/mL in controls, <i>P</i> = 0.3). However, 30% of diabetic patients exhibited abnormal sperm motility compared to 20% in controls, with odds ratios (ORs) of 1.7 for motility and 5.1 for abnormal morphology. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">The study highlights significant impairments in semen quality among Sudanese males with type 2 diabetes mellitus, emphasizing the need for further research into the underlying mechanisms and implications for male fertility. </span></span></span></span> Male infertility, Semen quality, Sperm morphology, Sperm motility, Type 2 diabetes mellitus 147 154 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-438-2&slc_lang=en&sid=1 Abdelkarim Abdrabo abdrabokarim@gmail.com 10031947532846004118 10031947532846004118 Yes Department of Nursing, Clinical Biochemistry, College of Applied Medical Sciences, Buraydah Private Colleges, Saudi Arabia. Sara Omer saraaljaw90@gmail.com 10031947532846004119 10031947532846004119 No Department of Clinical Chemistry, Faculty of Medical Laboratory Science, International University of Africa, Khartoum, Sudan. Walid Eldaif eldaifwah@gmail.com 10031947532846004120 0009-0002-9257-5233 No Department of Nursing, Microbiology, College of Applied Medical Sciences, Buraydah Private Colleges, Saudi Arabia.