Received on 18 May 2015 Accepted for publication on 3 August 2015

Background and Aims: Studies have not been able to prove an association between allergy and Helicobacter pylori (H. pylori) infection. The goal of this study is to evaluate the association of total immunoglobulin E (IgE) level, as a criterion for the presence of allergy, and H. pylori infection.

Methods and Materials: Seventy two patients with dyspepsia referring to endoscopy were included in this study. Anti-H. pylori IgG, anti-H. pylori-CagA IgG, and total plasma IgE levels were measured using enzyme linked immunosorbent assay and then statistically analyzed.

Results: Forty out of 72 patients had H. pylori infection, out of which 32 patients were CagA positive. Mean IgE level had a significant increase in the patients with H. pylori infection (p<0.05), but there was no significant difference between IgE levels of the CagA-positive and -negative groups (p=0.175).

Conclusion: Our study demonstrated a clear association between allergy and H. pylori infection.