The publication name of International Journal of Research in Applied and Basic Medical Sciences has changed to “Journal of Research in Applied and Basic Medical Sciences" and the new issue has been released in January 2020 under the new title.
The news related to the articles published in this issue are as follows:
An affinity-based method for the purification of platelet factor 4 from outdated platelet concentrates: This article describes a new method for isolating platelet factor 4 (PF4), a protein that has anti-inflammatory and anti-tumor properties, from expired platelet concentrates (PCs), which are blood products that are usually discarded after their shelf life. The method uses a synthetic peptide that binds to PF4 with high specificity and affinity, and allows the recovery of PF4 with high purity and yield.
Telfairia occidentalis Hook f. mitigates Carbon Tetrachloride induced Nephrotoxicity in Rat: This article investigates the protective effects of Telfairia occidentalis Hook f. (TOH), a medicinal plant that is widely used in Africa, on kidney damage caused by carbon tetrachloride (CCl4), a toxic chemical that induces oxidative stress and inflammation. The results show that TOH can prevent the elevation of serum creatinine and urea, the markers of kidney dysfunction, and reduce the histopathological changes in the kidney tissue of rats exposed to CCl4.
An Interesting Case with Extrapulmonary Manifestations of Sarcoidosis: This article reports a rare case of sarcoidosis, a chronic inflammatory disease that usually affects the lungs, but can also involve other organs. The case is a 45-year-old woman who presented with multiple extrapulmonary manifestations, such as skin lesions, eye inflammation, liver enlargement, spleen enlargement, and bone marrow involvement. The diagnosis was confirmed by biopsy and laboratory tests, and the patient was treated with corticosteroids and immunosuppressive drugs.
Analysis the Effectiveness of Remdesivir, Galidesivir, Sofosbuvir, Tenofovir and Ribavirin as Potential Therapeutic Drug target against SARS-Cov-2 RNA-Dependent RNA Polymerase (RdRp): An in Silico Docking Study: This article evaluates the potential of five antiviral drugs, namely remdesivir, galidesivir, sofosbuvir, tenofovir, and ribavirin, to inhibit the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, the virus that causes COVID-19. The article uses computational docking techniques to simulate the interactions between the drugs and the RdRp enzyme, and to compare their binding affinities and energies. The results suggest that remdesivir and galidesivir have the highest potential to block the RdRp activity and thus inhibit the viral replication.
Baseline aspartate aminotransferase activity is closely related to COVID-19 mortality: A bidirectional cohort study: This article examines the relationship between baseline aspartate aminotransferase (AST) activity, a liver enzyme that is often elevated in viral infections, and COVID-19 mortality. The article uses a bidirectional cohort study design, which compares the outcomes of COVID-19 patients with different levels of AST activity at admission, and also compares the prevalence of COVID-19 among individuals with different levels of AST activity before the pandemic. The results show that high AST activity is associated with increased risk of death from COVID-19, and also with increased susceptibility to COVID-19 infection.
A comparative study of radiological and functional outcome of multidirectional locking nail with locking plate for management of distal Tibial Metaphyseal fractures: This article compares two surgical methods for treating distal tibial metaphyseal fractures, which are fractures that occur near the ankle joint. The methods are multidirectional locking nail (MDLN) and locking plate (LP), which are both devices that stabilize the fractured bone segments with screws. The article evaluates the radiological and functional outcomes of 60 patients who underwent either MDLN or LP surgery, and finds that both methods have similar efficacy and safety in terms of fracture healing, pain relief, range of motion, infection rate, and complication rate.
Assessment of mean platelet volume in diabetes mellitus and its correlation with hba1c in normoglycemic, diabetic and prediabetic status: This article investigates the role of mean platelet volume (MPV), a measure of platelet size and activation, in diabetes mellitus (DM), a metabolic disorder that affects blood glucose regulation. The article measures the MPV levels and hemoglobin A1c (HbA1c) levels, which indicate the average blood glucose level over three months, in 150 individuals who are either normoglycemic (normal blood glucose), diabetic (high blood glucose), or prediabetic (impaired blood glucose). The results show that MPV levels are significantly higher in diabetic and prediabetic individuals than in normoglycemic individuals, and that MPV levels are positively correlated with HbA1c levels, suggesting that MPV may reflect the degree of glycemic control and vascular complications in DM.
Investigating the combined effect of ursolic acid and alpelisib on inhibiting cell proliferation and the expression of HIF1α on 4T1 breast cancer cell line: This article studies the synergistic effect of ursolic acid (UA) and alpelisib (ALP), two natural compounds that have anticancer properties, on the growth and survival of 4T1 breast cancer cells, which are a mouse model of aggressive and metastatic breast cancer. The article measures the cell viability, apoptosis, and expression of hypoxia-inducible factor 1 alpha (HIF1α), a protein that promotes tumor progression and resistance to therapy, after treating the cells with different concentrations and combinations of UA and ALP. The results show that UA and ALP can inhibit the cell proliferation and induce the cell death of 4T1 cells in a dose-dependent manner, and that UA and ALP can also suppress the expression of HIF1α in 4T1 cells. The results also show that UA and ALP have a synergistic effect, meaning that their combined effect is greater than their individual effects.
Study of gastrointestinal neoplasms, histopathologic and immunohistochemical correlation using HER-2/NEU, CK-7 and CK-20: This article analyzes the histopathologic and immunohistochemical features of gastrointestinal neoplasms, which are tumors that arise from the digestive tract. The article uses three biomarkers, namely human epidermal growth factor receptor 2 (HER-2/NEU), cytokeratin 7 (CK-7), and cytokeratin 20 (CK-20), which are proteins that are expressed on the surface of certain tumor cells and can help in the diagnosis and classification of gastrointestinal neoplasms. The article examines the expression of these biomarkers in 100 cases of gastrointestinal neoplasms, including gastric adenocarcinoma, colorectal adenocarcinoma, neuroendocrine tumor, gastrointestinal stromal tumor, and lymphoma, and finds that each biomarker has a different pattern of expression depending on the type and origin of the tumor.