en Serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I multiple myeloma تخصصي Special پژوهشي orginal article <strong><em>Background & Aims</em></strong>: Multiple myeloma (MM) is a type of plasma cell malformation accounting for 10% of the blood cancers with unknown ethiopathology. MM causes changes in inflammatory proteins. The aim of this study was to evaluate the serum levels of IL-6, TNF-&alpha;, and YKL-40 in patients with stage I MM<span dir="RTL">.</span><br> <strong>Materials & Methods:</strong> This case-control study was performed on 28 patients with stage I MM including 14 males and 14 females with mean age of 62.11 &plusmn; 6.71 years and 40 individuals as controls including 20 males and 20 females with mean age of 60.25 &plusmn; 4.81 years matched in both age and sex. Serum concentrations of inflammatory factors including IL-6, TNF-&alpha; and YKL-40 were measured using the sandwich Enzyme Linked Immunosorbent Assay (ELISA) method and the data were analyzed using SPSS software.<br> <strong>Results</strong>: The serum levels of IL-6 in patients with stage I MM (7.42&plusmn;5.89 pg/ml) were significantly higher compared to the control group (1.67&plusmn;1.08 pg/ml); (p< 0.0001). Also, the serum levels of YKL-40 in the patients (45.86 &plusmn; 9.14 ng/ml) were significantly higher compared to the control group (35.87 &plusmn; 11.2 ng/ml); (p <0.0001). Also, the levels of TNF-&alpha; (8.02&plusmn;1.75 pg/ml) were slightly high compared to the control group (7.77 &plusmn; 1.91 pg/ml); (p=0.419).<br> <strong>Conclusion:</strong> According to the results in MM, inflammatory proteins such as YKL-40 andIL-6 are the major growth factor of the myeloma cells and help their survival. Multiple myeloma, IL-6, TNF-α, YKL-40 160 166 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-101-13&slc_lang=en&sid=1 Zeinab Esmaeilzadeh monavvar03@gmail.com 1003194753284600874 1003194753284600874 No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Fatemeh Kheradmand kheradmand.f@umsu.ac.ir 1003194753284600875 1003194753284600875 No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Yousef Rasmi rasmiy@umsu.ac.ir 1003194753284600876 1003194753284600876 No Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran Mohammad Hassan Khadem-Ansari mhansari1@gmail.com 1003194753284600877 1003194753284600877 Yes Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran