en A comparative study on the effect of resistance training period with and without vascular occlusion hand on changes in fibrinogen, lipids, and lipoproteins in young girls تخصصي Special پژوهشي orginal article <strong><em>Background & Aims</em></strong>: &nbsp;Disorders of lipid profile and inflammatory markers are the most important factors that cause cardiovascular disease. Therefore, the aim of this study was to compare the effect of a six-week resistance training with and without vascular occlusion on changes in fibrinogen, lipids, and lipoprotein levels in young girls.<br> <strong><em>Materials & Methods:</em></strong> A total of 36 female students of physical education with an average age of 20.51 &plusmn;1.39 years and BMI of 23.32 &plusmn; 2.79 kg/m² were divided into three groups: resistance training without occlusion (exercise at 75% of one-repetition maximum or 1 RM), resistance training with vascular occlusion (exercise at 30% of 1 RM with a fastening tourniquet around the proximal arm), and a control group. Both training exercise groups performed a six-week training program consisting of three sessions per week. Then, creatine kinase (CK) levels, lipid profiles, and blood fibrinogen were measured by photometric, enzymatic, and ELISA methods, respectively.<br> <strong><em>Results:</em></strong> After six weeks of resistance training, CK levels were significantly different in both training groups (p < 0.05). Fibrinogen (FIB), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and cholesterol (COL) decreased significantly in both treatment groups compared to control group, but these changes were not statistically significant between the three groups (p > 0.05).<br> <strong><em>Conclusion:</em></strong> In our research, resistance training could probably improve cardiovascular health and metabolic states to change the fat as a kind of prevention against such diseases, hence, promotion of women&#39;s health should be taken into account. Resistance Training, Local Vascular Occlusion, Fibrinogen, CPK, Lipid (TG & TC), Lipoproteins (HDL-C & LDL-C) 134 143 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-121-1&slc_lang=en&sid=1 mahsa Porsesh mahsaporsesh8855@gmail.com 1003194753284600896 1003194753284600896 Yes PhD Student of Exercise Physiology, Department of Sport Physiology, Faculty of Sport Sciences, Shahid chamran University of Ahvaz, Ahvaz,Iran AbdolHamid Habibi Hamidhabibi330@gmail.com 1003194753284600897 1003194753284600897 No Professor, Departmen of Exercise Physiology, Shahid chamran University of ahvaz ,Ahvaz ,Iran shahram Solimani shahram_solimani@yahoo.com 1003194753284600898 1003194753284600898 No Master of Sport Physiology, Department of Sport Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran