en The Role of Radioprotector Agents in the Protection of Normal tissue عمومى General كاربردي review article The role of radioprotectors to reduce the cellular damage induced by ionizing radiation has been studied in human, animal and in vitro culture models. Radiation therapy cannot eradicate tumors successfully because of soft tissue damage. Proper use of radioprotective agents (before or shortly after radiation) can reduce normal tissue radiation toxicity and improve treatment output. There are three groups of radioprotectors: Synthetic protectors, antioxidant nutrients, and Immunomodulators. We discussed the radioprotective efficacy and its interaction against toxic agents. In addition, we discussed articles that have used radioprotective agents in the treatment of cancer with radiotherapy to protect normal tissue.<br> &nbsp; Radio protectors, Free radical, Antioxidant, Toxic substances, Radical scavenger 161 171 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-122-1&slc_lang=en&sid=1 Soraya Emamgholizadeh Minaei minayee.s@gmail.com 10031947532846002959 10031947532846002959 Yes Department of Medical Physics and Imaging, Urmia University of Medical Sciences, Urmia, Iran Farideh Hoseini 10031947532846002960 10031947532846002960 No Department of radiology technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran