en بررسی فعالیت های ضد دیابتیکی و آنتی اکسیدانی عصاره برگ های سیلیندریکوم ENTANDROPHRAGMA در موش های صحرایی نر ویستار عمومى General پژوهشي orginal article <strong><em>Background & Aims</em></strong>: &nbsp;<em>Entandrophragma cylindricum</em> (<em>EC) is</em> a tree with a widespread presence in various West African countries. It has wide folkloric use as an anti-sickling, antimalarial, analgesic, anti-inflammatory, and is widely used traditionally in treating diabetes across West Africa. The purpose of this research is to evaluate the antidiabetic potential of the methanolic leaf extract of <em>Entandrophragma cylindricum</em> (<em>EC) </em>in rats.<br> <strong><em>Materials and Methods</em></strong><em>:</em> Induction of Diabetes mellitus was done by Streptozotocin (STZ) via intraperitoneal route injection. Animals were apportioned into five groups (n=5) for contrasting the activity of <em>EC</em> at three <em>EC</em> doses (25 mg/kg, 50 mg/kg, 150 mg/kg p.o.) against the standard drug (Glibenclamide) and control groups. Rats having elevated glucose levels above 250 mg/dL were considered diabetic and used for the study. Normoglycemic test, Oral Glucose Tolerance Test (OGTT), STZ-Induced diabetes, in-vitro antioxidant properties of <em>EC</em> extract, and <em>in</em> vivo antioxidant property of the serum were assessed.<br> <strong><em>Results</em></strong>: Phytochemistry revealed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, deoxy-sugars, and anthraquinones. The three doses of <em>EC</em> (150, 50, and 25 mg/kg) used in the study caused a significant decrease in blood glucose levels in the STZ-induced diabetic rat model. Also, <em>EC</em> (150, 50, and 25 mg/kg) produced a significant (p< 0.001) increase respectively in the body weight from day 0 to day 30 when compared with the untreated diabetic rat. Our results indicated that <em>EC</em> might be a potent free radical scavenger, as it scavenged the 2,2 -diphenyl picrylhydrazyl (DPPH) radical, hydroxyl radical, and NO radicals <em>in</em> vitro. <em>EC</em> also showed a significant anti-lipid peroxidative effect <em>in</em> vivo. Histologic analysis revealed the regenerative impact of EC on the &beta;-cells of diabetic rats.<br> <strong><em>Conclusion</em></strong><em>:</em> Findings revealed that <em>EC</em> possess antihyperglycemic and antioxidant effects. Entandrophragma cylindricum, Diabetes mellitus, antioxidant, antidiabetic 108 121 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-160-1&slc_lang=en&sid=1 Farouk Oladoja adedeji.oladoja@oouagoiwoye.edu.ng 10031947532846001223 10031947532846001223 Yes Olabisi Onabanjo University Emmanuel Irokosu emmanuel.irokosu@oouagoiwoye.edu.ng 10031947532846001224 10031947532846001224 No Olabisi Onabanjo University Oluwafemi Kale Kale.oluwafemi@oouagoiwoye.edu.ng 10031947532846001225 10031947532846001225 No Olabisi Onabanjo University Taiwo Olubodun-Obadun olubodunobaduntaiwo@gmail.com 10031947532846001226 10031947532846001226 No University of Lagos