Journal of Research in Applied and Basic Medical Sciences

en A comparison of the Effects of Low and High Doses of Corticosteroids on Recovery of the Patients with Covid-19 عمومى General پژوهشي orginal article Background & Aims: SARS-CoV-2 is a new coronavirus type that first appeared in Wuhan, China, and caused a pandemic of respiratory diseases from the end of 2019. Severe infections of this virus can cause incorrect adjustments of cytokine and chemokine responses, which ultimately causes damage to the lung tissue. Corticosteroids are a class of drugs that reduce inflammation and immune system activities in the body. For this reason, many doctors and researchers thought of using corticosteroid treatments to control the cytokine storm. Materials & Methods: In this retrospective descriptive cross-sectional study, the files of Covid-19 patients who were admitted to Shahid Mohammadi Hospital, Bandar Abbas, Iran, were examined. On the basis of the severity, the patients were grouped into two groups of moderate and severe patients. Patients in each group were then sub-categorized into high dose and low dose, according to the received dose of corticosteroids. Then we investigated the effect of different doses of corticosteroids on the course of recovery of Covid-19 cases. Results: In the severe group, the patients who received high-dose of corticosteroids had a higher mortality rate as compared to the low-dose group. In both the severe and moderate groups, the LDH level of the patients who received low doses of corticosteroids at the time of discharge were significantly less compared to those who received high doses. In the moderate group, the percentage of lymphocytes in the low-dose corticosteroid group was considerably higher compared to the high-dose corticosteroid group at the time of discharge. Conclusion: According to the results, in the case of patients with moderate clinical severity, a low dose of corticosteroids improved the disease, but in the case of patients with severe clinical severity, the results were contradictory, which may be caused by interference of other factors such as underlying diseases, the severity of the illness, etc. in the severe group. Corticosteroids, Covid-19, Mortality 62 70 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-152-3&slc_lang=en&sid=1 Hamid Reza Samimagham samimagham@yahoo.com 10031947532846002541 10031947532846002541 No 1 Clinical Research Development Center, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Ladan Hajiabdolrrasouli Lhajirassouli@gmail.com 10031947532846002542 10031947532846002542 No Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran Ali Salimi Asl Shervin7717@gmail.com 10031947532846002543 10031947532846002543 No Student Research Committe,Faculty of Medicie, , Hormozgan University of Medical Sciences, Bandar Abbas, Iran Fatemeh Khajavi Mayvan fatemehkhajavi18@gmail.com 10031947532846002544 10031947532846002544 No Student Research Committe,Faculty of Medicie, , Hormozgan University of Medical Sciences, Bandar Abbas, Iran Elham Boushehri elhamboushehri@yahoo.com 10031947532846002545 10031947532846002545 No Medical Education Department,Health School, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Mohsen Arabi drmohsenarabi@gmail.com 10031947532846002546 10031947532846002546 No Preventive Medicine and Public Health Research Center, Family Medicine Department, Iran University of Medical Sciences,Tehran, Iran Mohammad Amin Abbasi Amin.abbasi1314@gmail.com 10031947532846002547 10031947532846002547 No Firoozabadi Hospital Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran Mohammad Reza Moradi mohammadrezamoradi@gmail.com 10031947532846002548 10031947532846002548 No Student Research Committe,Faculty of Medicie, , Hormozgan University of Medical Sciences, Bandar Abbas, Iran Mitra Kazemi Jahromi mitra.kazemijahromi@gmail.com 10031947532846002549 10031947532846002549 Yes Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran