Journal of Research in Applied and Basic Medical Sciences

en Platelet indices in acute coronary syndrome patients عمومى General پژوهشي orginal article Background & Aims: platelets play crucial role in acute coronary syndromes (ACS). The importance of platelets in the development and spread of acute coronary syndromes (ACS) is well known. Most studies tried to find an association between platelet indices and cardiovascular diseases (CVD) risk factors; however, the results contradict, and despite the relative ease of obtaining the platelet indices, their use in clinical practice is still limited. This study aimed to investigate the relationship between platelet indices and other influencing factors including age, gender, underlying diseases, and fat profile in determining the risk of ACS. Materials & Methods: From September 2019 to March 2020, a consecutive of 101 patients (76 men and 25 women) admitted to the CCU in firoozabadi hospital, Tehran, Iran, were enrolled in this cross-sectional study. Patients who had a history of platelet disorders, myeloproliferative disorders, thyroid dysfunctions, receiving blood products, cancers and chemotherapy, and patients who had missing Mean platelet volume (MPV) in current or prior admissions were excluded from the study. Patients were divided into the MI and the UA (Unstable Angina) groups. Data were presented as means ± SD and qualitative variables as frequency (percentage) were considered. Statistical analyzes were performed with SPSS software version 20. Results: The mean age of patients was 62.5 ± 13.16 years. Age, gender, underlying disease, troponin, ejection fraction, HDL, LDL, cholesterol, and triglyceride were assessed in the patients. The mean fasting blood sugar and LDL were significantly different between the two groups of MI and Unstable Angina (UA), in which P-values were 0.001 and 0.02, respectively. Comparing platelet indices, including platelet count, PDW, and MPV in the two groups, indicated a difference in the PDW variable (P-value 0.008). Conclusion: Platelet count did not show any significant changes or relation with MI and UA patients. MPV was not significantly higher in the MI group than the UA group, but higher MPV values were related to a higher mortality rate. Elevated PDW was significantly correlated with both MI groups and mortality, thus can be used as a prognostic factor. Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction, Platelet 71 79 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-134-5&slc_lang=en&sid=1 Shahin Keshtkar Rajabi sh_rajabi64@yahoo.com 10031947532846002550 10031947532846002550 No Firoozabadi hospital clinical research development unit (FHCRDU), Department of internal medicine, school of medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran Faeze Delpasand Delpasandf@gmail.com 10031947532846002551 10031947532846002551 No Firoozabadi hospital clinical research development unit (FHCRDU), Department of internal medicine, school of medicine, Iran University of Medical Sciences (IUMS), Tehran, Ira Soroush Nematollahi Soroushne.md@gmail.com 10031947532846002552 10031947532846002552 No MD, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Soleimani Soleimani1995m@gmail.com 10031947532846002553 10031947532846002553 No Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Ehsan Rikhtegar Rikhtegar.e@umsu.ac.ir 10031947532846002554 10031947532846002554 No Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Mohammad Amin Abbasi Amin.abbasi1314@gmail.com 10031947532846002555 10031947532846002555 Yes Firoozabadi hospital clinical research development unit (FHCRDU), Department of internal medicine, school of medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran