fa تخصصي Special پژوهشي orginal article <strong>Background & Aims:</strong> Rheumatoid Arthritis (RA) is one of the common autoimmune diseases with unknown etiology. It has been suggested that antioxidant supplements may play a role in inflammation perpetuating process. This study examined the influence of combined antioxidant supplementation on serum asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF) levels and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers in RA patients.<br> <strong>Materials & Methods</strong>: A three-month pre-post study was conducted on 40 female RA patients receiving one Selenplus capsule (Selenium 50&mu;g, Zinc 8 mg, vitamin A 400 &mu;g, vitamin C 125 mg and vitamin E 40 mg) daily.&nbsp;5 ml venous blood samples were taken from all the participants before and after the administration period. The serum levels of ADMA, VEGF and high-sensitivity C-reactive protein (hs-CRP) were measured by standard methods.<br> <strong>Results:</strong> 39 out of 40 patients completed the study. In comparison with the baseline, we did not find any significant differences between serum ADMA and VEGF values before and after the intervention. The 3-month use of SelenPlus supplementation resulted in decreasing hs-CRP level (p<0.003).<br> <strong>Conclusion:</strong> The combined antioxidant supplements for 3 months decreased serum hs-CRP levels in RA patients that may be helpful in RA treatment. The hs-CRP reduction may due to the anti-inflammatory effects of Zinc and Selenium in SelenPlus supplement.&nbsp;<br> &nbsp; Rheumatoid Arthritis, Antioxidant, ADMA, VEGF, C-reactive protein 20 26 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-77-1&slc_lang=fa&sid=1 Sousan Kolahi susan.kolahi@gmail.com 1003194753284600470 1003194753284600470 No Professor of Rheumatology, Drug Applied Research Center, Connective Tissue Diseases Research Center, Tabriz University of Medical Amir Ghorbanihaghjo ghorbaniamir@hotmail.com 1003194753284600471 1003194753284600471 Yes Professor of Biochemistry, Drug Applied Research Center, Tabriz University of Medical Sciences Sina Raisi sina_raeisi7007@yahoo.com 1003194753284600472 1003194753284600472 No PhD student, Drug Applied Research Center, Tabriz University of Medical Sciences Arezou Ghasmebaglou Ghasmebaglou@yahoo.com 1003194753284600473 1003194753284600473 No Internal medicine Resident, Drug Applied Research Center, Tabriz University of Medical Sciences Mahsa Jalili mahsajalilii@hotmail.com 1003194753284600474 1003194753284600474 No Nutrition Faculty of Tabriz University of Medical Sciences Amir Teimouri Dereshki Dereshkiamuirtaimor@yahoo.com 1003194753284600475 1003194753284600475 No Medical student of faculty of medicine, Tissue Diseases Research Center Tabriz University of Medical Sciences Alireza i Khabbaz dr_khabbazi@yahoo.com 1003194753284600476 1003194753284600476 No Assistant Professor of Rheumatology, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran