Journal of Research in Applied and Basic Medical Sciences

en - Tracking of the Maillard reaction products in oral liquid formulation of sertraline hydrochloride تخصصي Special پژوهشي orginal article <div style="text-align: justify;">In the present paper the physicochemical incompatibility of sertraline with dextrose was evaluated in oral liquid formulations. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and mass spectrometry were applied to assess sertraline - dextrose incompatibility. Non-Isothermally stressed physical mixtures were used to study the solid–state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) were used to calculate the activation energy of drug-excipient interaction.<br> The aim of this study was to evaluate the kinetic parameters using a fast and sensitive DSC method.<br> Overall, the incompatibility of sertraline as an amine containing drug with dextrose as a reducing carbohydrate was successfully evaluated. DSC based kinetic analysis can provide rapid and easy evaluation of different drug-excipient mixtures incompatibilities. Special considerations should be made regarding the Maillard incompatibility reaction in the formulation design of liquid formulations containing dextrose or natural herbal extracts as sweeteners.<br>  </div> Sertraline, Dextrose, Incompatibility, Kinetic, DSC, Mass 1 10 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-90-1&slc_lang=en&sid=1 Faranak Ghaderi f.ghaderi1390@gmail.com 1003194753284600460 1003194753284600460 No Department of Pharmaceutical and Food Control, School of pharmacy, Urmia University of Medical Sciences, Urmia, Iran mahboob nemati nematim@tbzmed,ac.ir 1003194753284600461 1003194753284600461 No Department of Pharmaceutical and Food Control, Faculty of pharmacy Tabriz, University of Medical Sciences, Tabriz, Iran mohammad reza siahi siahimr@tbzmed.ac.ir 1003194753284600462 1003194753284600462 No Food and drug safety research center, Tabriz University of Medical Sciences, Tabriz, Iran hadi valizadeh valizadeh@tbzmed.ac.ir 1003194753284600463 1003194753284600463 No Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran farnaz monajjemzadeh monajjemzadehf@yahoo.com 1003194753284600464 1003194753284600464 Yes Department of Pharmaceutics, Tabriz University of Medical Sciences, Faculty of pharmacy, Tabriz, Iran