en Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats عمومى General پژوهشي orginal article In this study, we evaluated the effect of tropisetron on the oxidative biomarkers in the plasma of type 1 diabetes mellitus (DM). Twenty-one male Wistar rats were randomly divided into three experimental groups (n =7): control, diabetic and diabetic + tropisetron. Diabetes type 1 was induced by streptozotocin (STZ) (50 mg/kg; i.p). Tropisetron (3 mg/kg; i.p) as a 5-HT3 antagonist was given once daily for 2 weeks. At the end of experiment animals were euthanized and blood samples were collected for further analysis including superoxide dismutase (SOD), glutathione peroxidase (GPx) activities and malondialdehyde (MDA), total antioxidant capacity (TAC) levels. We found that tropisetron attenuated MDA levels and increased SOD, GPx and TAC contents in the plasma of diabetic rats. Our findings indicate that tropisetron improved oxidative stress in the plasma of STZ induced-diabetic rats. Diabetes, Tropisetron, Oxidative stress, Rat 102 107 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-98-1&slc_lang=en&sid=1 Shiva gholizadeh-Ghaleh Aziz doctorgholizadeh@gmail.com 1003194753284600452 1003194753284600452 No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Roya Naderi r_naderi_s@yahoo.com 1003194753284600453 1003194753284600453 Yes Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Naser Khalaji Khalaji.Naser@Gmail.com 1003194753284600454 1003194753284600454 No Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Nima Mahmodian mahmodian@yahoo.com 1003194753284600455 1003194753284600455 No Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran