en Comparison of traditional prenatal diagnosis procedures and Cell-Free DNA in maternal plasma as a new molecular approach for prenatal diagnosis تخصصي Special كاربردي review article Cell-free DNA (cfDNA) is a moderately novel method with an exponential expansion in uses for a wide range of applications. The clinical services of these new techniques will be estimated by the scientist in the field via the newest case studies. Non-invasive detection of cell-free DNA has the potential to impact treatment regimens and clinical protocols. cfDNA will manage the standard of care in transplant medicine, oncology, and cardiovascular disease. This field is appearing as one of the most exciting and promising areas of medicine and other sciences and can make a huge influence on prenatal care. The aim of this review is to present potential and application of Cell-Free DNA in prenatal diagnosis. Cardiovascular disease, Cell-Free DNA, Prenatal diagnosis, Non-invasive 108 118 http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-99-1&slc_lang=en&sid=1 Ghader Babaei ghaderbiochem@gmail.com 1003194753284600456 1003194753284600456 No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Roya Naderi r_naderi_s@yahoo.com 1003194753284600457 1003194753284600457 No Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Shahriar Alipour alipourshahriar17@gmail.com 1003194753284600458 1003194753284600458 No Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Shiva Gholizadeh-Ghaleh Aziz doctorgholizadeh@gmail.com 1003194753284600459 1003194753284600459 Yes Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran