Journal of Research in Applied and Basic Medical Sciences
Journal of Research in Applied and Basic Medical Sciences
Medical Sciences
http://ijrabms.umsu.ac.ir
1
admin
2717-0098
8
10.61186/rabms
14
8888
13
en
jalali
1397
12
1
gregorian
2019
3
1
5
1
online
1
fulltext
en
Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract
Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract
عمومى
General
پژوهشي
orginal article
Crocus Sativus Petals are a dusted waste that contains bioactive compounds. The aim of this study was to evaluate the cytotoxicity, antioxidant, antibacterial activities of Crocus Sativus petals extract (CSPE). The cytotoxic effects of CSPE on human liver cancer cells (HepG2) were performed using MTT assay. Then, cell morphology was determined by inverted microscope. The antioxidant activity of CSPE was evaluated using DPPH and ABTS assays. Antibacterial activity of CSPE was tested against gram-negative bacteria <em>Escherichia coli (E. coli)</em> and gram positive bacteria <em>staphylococcus aureus (S. aureus)</em> using macrodilution method. CSPE inhibited the proliferation of the HepG2 cell line in a time and dose-dependent manner, which was consistent with morphological changes. Extract showed the enhanced antioxidant properties and also were found effective against the bacterial strains. Due to the anti-proliferative, antioxidant, antibacterial effects of CSPE, it can be used in pharmaceutical industry, including the production of anticancer, antioxidants and antibacterial drugs.
Crocus Sativus petal extract, HepG2, antioxidant activity, antibacterial activity, pharmaceutical industry
69
76
http://ijrabms.umsu.ac.ir/browse.php?a_code=A-10-102-1&slc_lang=en&sid=1
Ashraf
Ahmadi Shadmehri
ahmadi492004@yahoo.com
1003194753284600548
1003194753284600548
No
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Farideh
Namvar
nanoscience96@yahoo.com
1003194753284600549
1003194753284600549
Yes
Department of Medicine & Applied Biology Research Centre, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Hamidreza
Miri
hr.miri1354@gmail.com
1003194753284600550
1003194753284600550
No
School of medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Parichehre
Yaghmaei
yaghmaei_p@yahoo.com
1003194753284600551
1003194753284600551
No
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mahboobeh
Nakhaei Moghaddam
mahboobe_nak@yahoo.com
1003194753284600552
1003194753284600552
No
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran