@article{ author = {Zolfaghari, Mohammad Reza and Jafarlu, Mehdi and Shamizadeh, Mahdiyeh and Fattahi, Amir}, title = {Effects of exhaustive training with L-arginine consumption on inflammation and oxidative stress biomarkers in young bodybuilders}, abstract ={Background & Aims: The acute exercise causes induction of oxidative stress and inflammatory responses. Considering anti-inflammatory and antioxidant properties of L-arginine, in this study we have investigated effects of L-arginine consumption on inflammatory and oxidative stress biomarkers following exhaustive training in young bodybuilders. Materials & Methods: In an interventional study, 30 young bodybuilders were divided into two equal groups, placebo (consuming L-arginine) and supplementation (consuming dextrose). Each individual received 3 g/day of L-arginine or dextrose for one week. During the supplementation, all participants performed one week exhaustive training according the specific protocol. Blood samples were collected before (at baseline) and immediately after first training session (for evaluating acute effects) and also after one week training. Finally serum levels of C-reactive protein (CRP), interleukin-6 (IL6), malondialdehyde (MDA) and activity of superoxide dismutase (SOD) were determined in all samples by ELISA. Results: The results showed that exhaustive training caused a significantly increase in levels of CRP, MDA and IL6 (p<0.05). Our results revealed that the L-arginine consumption could prevent exercise-induced increasing in concentration of these factors following trainings. Also, positive correlations were observed between CRP with IL6, CRP with MDA and IL6 with MDA before the training. Conclusions: Performing acute and chronic exhaustive training even in athlete causes increasing in inflammatory and oxidative biomarkers and consumption of L-arginine could modulate chronic and acute exhaustive exercise-induced oxidative stress and inflammatory responses.  }, Keywords = {Inflammation, Oxidative stress, Exercise trainings, Arginine}, volume = {5}, Number = {1}, pages = {1-8}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-75-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-75-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Kashi, Samaneh and shirpoor, Alireza and Kheradmand, Fatemeh and Pourjabali, Masoumeh and Rasmi, Yousef and Zeynali-moghaddam, Shim}, title = {Prenatal and early postnatal ethanol exposure induces hepatic transcriptional factors, gene expression transition and structural changes in the liver of offspring: A three month follow-up}, abstract ={Background & Aims:  The aim of the present study was to investigate the effect of maternal pre- and early postnatal ethanol consumption on hepatic transcriptional factors, gene expression transition, liver enzymes alteration, as well as structural changes in the developing rat liver both on  postnatal (PN) day 21 and 90. Materials & Methods: Pregnant Wistar rats received ethanol (4.5g/kg BW) once per day from Gestation Day (GD) 7 throughout lactation. The mRNA expression of hepatic Fatty Acid Translocase (FAT)/CD36, Protein Tyrosine Phosphatase 1B (PTP1B) and Hepatocyte Nuclear Factor 4 Alpha (HNF4A) gene expressions, as well as liver structural changes were measured in 21 and 90 day-old offspring of ethanol rats and were then compared to the control rats. Results:  Ethanol exposed fetal livers showed a significant up-regulation in FAT / CD36, PTP1B and down-regulation in HNF4A gene expression, as well as an increase in the liver alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the offspring on PN 21 and PN 90 compared to the offspring in the control group. In addition, in the ethanol group, cholesterol levels showed a significant increase on PN 21 and PN 90, and triglyceride showed an increase on PN 90, compared to the control group. Histopathological changes, such as ballooning degeneration, feathery degeneration, spotty necrosis, cholestasis, and fibrosis were also observed in the liver of the offspring after 21 and 90 days from birth. Conclusion: In conclusion, results of the current study provide evidence that prenatal ethanol exposure influences liver lipid metabolism through hepatic transcriptional factors, gene expression transition and hepatic enzyme including ALT and AST changes.  }, Keywords = {pregnancy, Ethanol, FAT / CD36, PTP1B, lipid}, volume = {5}, Number = {1}, pages = {9-17}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-77-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-77-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Dolatkhah, Neda and Hajifaraji, Majid and Abbasalizadeh, Fatemeh and Aghamohammadzadeh, Naser and Jahanjou, Fatemeh and Shakouri, Seyed Kazem}, title = {Effect of probiotics on quality of life and depression in pregnant women with gestational diabetes: A randomized double-blinded clinical trial}, abstract ={Background & Aims:  Women are vulnerable and face variety of problems during pregnancy that can affect mental health and life quality. Pregnancy complications make pregnant women more prone to loss of quality of life and mental health problems. The purpose of this study was to investigate the effect of probiotic supplement on quality of life and depression in women with gestational diabetes mellitus (GDM). Materials & Methods: In this double blind randomized clinical trial, performed on pregnant women with GDM referring to the specialized centers of gynecology and endocrinology in Tabriz, 64 pregnant women with GDM in 24-28 weeks of pregnancy were randomly assigned to receive either probiotic supplementation or placebo for 8 weeks. Probiotic supplement was a combination of four strains of Lactobacillus acidophilus, Bifidobacterium, Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. The short form of Iranian species of World Health Organization Quality of Life Questionnaire was used to assess the quality of life and the Edinburgh Depression Inventory to assess depression before and after intervention. Results: Fifty six surveyed individuals completed the study. The effect of probiotic supplementation on changes in the physical dimension of quality of life was significant, with statistically remarkable increase of 2.59 ± 2.19 units in the probiotic group compared with 2.25 ± 0.88 decrease in the placebo group (p = 0.045). Also, the increase in mean of total quality of life in the probiotic group was 5.17 ± 1.46 units which was significant compared with 0.46 ± 1.61 units increase in the placebo group (p = 0.029). The effect of probiotic supplementation in comparison with placebo was significant in improving depression (p = 0.042). Conclusions: It seems that probiotic supplementation promotes quality of life and depression levels in pregnant women with GDM. Registration number in Iranian Registry of Clinical Trials: IRCT201405181597N3  }, Keywords = {Gestational diabetes mellitus, Probiotic, Quality of life, Depression}, volume = {5}, Number = {1}, pages = {18-29}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-78-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-78-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Shirpoor, Alireza and NezamiMajd, Faride and Gaderi, REZA and Naderi, Roy}, title = {Comparison of myocardial apoptosis in 21 and 90 days after birth in pups induced by maternal long term ethanol consumption}, abstract ={Background & Aims: This study was designed to assess and the cardiac apoptosis after the prenatal and early postnatal ethanol treatment in pups. Materials and Methods: Pregnant Wistar rats treated with ethanol 4.5g/kg BW once per day from the seventh day of gestation (GD7) throughout lactation. Apoptotic cells, body wight, heart weight and their association on postnatal day 21 (PN-21) and postnatal day 90 (PN-90) was evaluated in male pups. Results: The results showed that maternal ethanol consumption increased apoptotic cells, decreased heart weight, body weight, and HW/BW after 21 and 90 days of birth compared with the controls. It has found more apoptotic cells in 90 days after births compared with 21 days of age. Conclusions: our findings revealed that maternal ethanol intake in pups decreased HW/BW ratio in part through apoptosis, which is more predominant in 90 days of age.}, Keywords = {Ethanol, Offspring, Apoptosis, Heart}, volume = {5}, Number = {1}, pages = {30-35}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-73-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-73-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Hosseini, Mahbubeh and Qujeq, Durdi and Tamaddoni, Ahmad and Ranaee, Mohammad and Hajian-Tilaki, Karimollah}, title = {Effects of Anethum graveolens, Urticadioica, Milk thistle Aqueous Extract and Deferoxamine on total iron binding capacity ,iron and ferritin levels}, abstract ={Background & Aims: Iron overload is one of the medical problems in some diseases. Recent reports have indicated a need for iron chelator. In this study, the possible iron chelating properties of aqueous extracts of A.graveolens, Urtica dioica and milk thistle on total iron binding capacity, iron and ferritin levels in iron overloaded rats were investigated. Materials & Methods: Fresh A.graveolens and Urtica dioica leaves and milk thistle seeds were obtained from the local market. Fortyeight male rats were randomly divided into six groups: negative control (normal), positive control (iron overload) and groups treated with deferoxamine (DFO), aqueous extracts of A.graveolens, Urtica dioica and milk thistle. Iron dextran was injected intraperitoneally (i.p.) at 50mg/kg body weight/day to establish the iron overload for twelve weeks. Normal group rats received normal saline, while the rats of the treated groups received (orally) aqueous extracts of A.graveolens, Urtica dioica and Milk thistle and DFO daily for eight weeks. Changes in biochemical factors were measured at the end of the experiment. Results: After twelve weeks of iron dextran treatment, we found a significant increase in iron and ferritin levels and a decrease in total iron binding capacity (TIBC) level compared to normal group (229.0±5.85, 181.22±5.53 and 200.54 ±1.51 vs. 131.90±6.85, 50.25 ±4.01 and 291.71, respectively). After eight weeks of treatment with extracts and DFO, there was significant reduction in serum iron level of extracts of A.graveolens, Urtica dioica and milk thistle and DFO treated groups compared to iron overloaded group (185.81±3.5, 180.88±2.73, 200.6±2.44, 176.48 ±2.29 vs. 229.0±85.5). Also, there was a significant increase in serum TIBC level in the extracts of A.graveolens, Urtica dioica and milk thistle and DFO treated groups compared to iron‑overloaded rats (218.62±2.44, 226.74±2.71, 211.06±1.86, 231.57 ±2.05 vs. 200.54±1.51, respectively). Furthermore, there was a significant reduction in serum ferritin level in the extracts of A.graveolens, Urtica dioica and milk thistle and DFO treated groups compared to iron‑overloaded rats (130.49±4.24, 121.96±4.31, 140.63±3.82, 112.87 ±4.60 vs.181.22±5.53). So after eight weeks treatment with aqueous extracts of A.graveolens, Urtica dioica and milk thistle, we found a significant reduction in iron and ferritin and an increase in TIBC level. These effects indicated the following hierarchy: Urticadioica >Anethum graveolens > milk thistle. Conclusion: Anethum graveolens, Urtica dioica and milk thistle extracts may be a potential herbal plant to reduce liver damage caused by iron overload. These results indicated that Anethum graveolens, Urtica dioica and milk thistle extracts can preserve liver function.}, Keywords = {Aqueous extract, Anethum graveolens, desferrioxamine, Urtica dioica and milk thistle}, volume = {5}, Number = {1}, pages = {36-43}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-76-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-76-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Diba, Kambiz and Alizadeh, Zahra and Mokhtari, Fatemeh and Yekta, Zahr}, title = {Common fungi and major factors of the contamination of student dormitories indoor}, abstract ={Background & Aims:  Microbiological quality of environments is an important criterion that must be taken into account when indoor workplaces are designed to provide a safe environment.  Therefore the purpose of this study is to provide insight into how students are exposed to fungal contamination of the dormitory indoor and to figure out the major possible factors that govern the contamination levels. Material & Methods: The study samples were obtained from two female dormitories of UMS University. The specimens were collected by using sterile swabs from indoor environments such as rooms, kitchens, washrooms /bathrooms, corridors and study rooms. A morphologic identification was performed using colony features and microscopic characteristics for the fungal isolates, and the findings were confirmed by PCR-RFLP molecular method. Results: Molds and yeasts were recovered from the indoor places including rooms, study room, kitchens and bathrooms from student life areas of the dormitories. A total of 160 swab samples yielded fungal growth. The number of fungal colonies recorded was 458 cps (colony per swab) included common mold: A. flavus (31.7%), A. fumigatus (28.7%), A. niger (5.8%) and yeasts: Candida albicans, C. dubliniensis, C. krusei. The black fungi (dematiaceus fungi) were totally isolated 67 (11.5%) followed by other molds included Penicillium (9.5%), Rhizopus (4.3%), Scopolariopsis (0.5%), Pseudoallescheria and Fusarium (0.35% each). Conclusion: Our findings show that Aspergillus species are most common fungi contaminant dormitories indoor and kitchens contain most species and numbers of molds.  }, Keywords = {Fungi, Contamination, Dormitory, Rush Hour, Free Time}, volume = {5}, Number = {1}, pages = {44-49}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-80-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-80-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Mehryar, Hamid Reza and Khaffafi, Behrang and Shadfar, Faezeh and Khoshakhlagh, Hadi and Rezazadeh, Farzin and choobianzali, babak}, title = {The Potential risk factors of Ischemic stroke incidence and mortality}, abstract ={Background & Aims: Ischemic stroke is always more common than hemorrhagic type. Approximately, 80% of the risk factors involved in the pathogenesis of stroke are modifiable. Identification and correction of these risk factors contributes to reducing the risk of stroke incidence, subsequent clinical consequences, disabilities, costs, and mortality of these patients. Materials & Methods: In this retrospective cross-sectional study, 1,572 patients with ischemic stroke hospitalized during 2008-2015 were investigated. Patients data was collected in a questionnaire containing demographic information, drug and disease history, laboratory findings and events during hospitalization and follow-up period. Results: Among 1,572 patients, 744 (47.3%) were male and 828 (52.7%) female. The number of patients who died during hospitalization was 252 (16%) and 453 (34.3%) died during the follow-up period. The most important modifiable risk factors for stroke incidence included smoking, hypertension, dyslipidemia, and diabetes mellitus. Also, the use of aspirin in both genders and statin consumption in males was associated with decreased rate of mortality. A series of laboratory findings, such as increased urea, creatinine, fasting blood glucose, cholesterol and neutrophil count, was associated with an increased risk of mortality as well as, decreased lymphocyte count, increased RBC, hemoglobin, platelet count, and triglyceride were associated with a reduction in stroke mortality. Conclusion: This study confirms the results of previous studies about modifiable risk factors of ischemic stroke incidence such as diabetes, hypertension, dyslipidemia, and smoking. Laboratory findings such as neutrophil, lymphocyte, platelet count, hemoglobin, urea, RBC, lipid and glucose profiles associated with ischemic stroke mortality. Life style modification and preventive medication such as aspirin and statins reduce the risk of stroke incidence, disability and mortality of ischemic stroke in the community.  }, Keywords = {Ischemic stroke, Incidence, Mortality}, volume = {5}, Number = {1}, pages = {50-68}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-79-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-79-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {AhmadiShadmehri, Ashraf and Namvar, Farideh and Miri, Hamidreza and Yaghmaei, Parichehre and NakhaeiMoghaddam, Mahboobeh}, title = {Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract}, abstract ={Crocus Sativus Petals are a dusted waste that contains bioactive compounds. The aim of this study was to evaluate the cytotoxicity, antioxidant, antibacterial activities of Crocus Sativus petals extract (CSPE). The cytotoxic effects of CSPE on human liver cancer cells (HepG2) were performed using MTT assay. Then, cell morphology was determined by inverted microscope. The antioxidant activity of CSPE was evaluated using DPPH and ABTS assays. Antibacterial activity of CSPE was tested against gram-negative bacteria Escherichia coli (E. coli) and gram positive bacteria staphylococcus aureus (S. aureus) using macrodilution method. CSPE inhibited the proliferation of the HepG2 cell line in a time and dose-dependent manner, which was consistent with morphological changes. Extract showed the enhanced antioxidant properties and also were found effective against the bacterial strains. Due to the anti-proliferative, antioxidant, antibacterial effects of CSPE, it can be used in pharmaceutical industry, including the production of anticancer, antioxidants and antibacterial drugs.}, Keywords = {Crocus Sativus petal extract, HepG2, antioxidant activity, antibacterial activity, pharmaceutical industry}, volume = {5}, Number = {1}, pages = {69-76}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-82-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-82-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {HosseiniJazani, Nima and Shahabi, Shahram}, title = {Gut Microbiota, Dysbiosis and Immune System; A Brief Review}, abstract ={The gut Microbiota is the large population of microorganisms residing in the human gastrointestinal tract. The gut Microbiota constantly interacts with the various host organs and systems. While there are many protective functions due to the gut Microbiota, changes in the composition and function of the Microbiota, which is defined as dysbiosis, has been shown in several diseased conditions. The gut Microbiota affect the immune system. While normal gut Microbiota are essential for existence of a normal immune system, dysbiosis can result in deviation of immune responses. In this article, we will talked the effects of the gut Microbiota on different elements of immune system.}, Keywords = {Gut Microbiota, Dysbiosis, Immune System, Inflammation}, volume = {5}, Number = {2}, pages = {77-81}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-90-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-90-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Dolatkhah, Neda and Hajifaraji, Maji}, title = {Probiotics and Metabolic Outcomes of Gestational Diabetes: A Review Article}, abstract ={Gestational diabetes mellitus (GDM) is the most prevalent metabolic problem of gestation. In contrast to subjects without diabetes, women with GDM are at advanced risk of adverse maternal and fetal consequences without intervention. The current and unanticipated growth in the prevalence of gestational diabetes and the middling outcomes of dietary manipulations could somewhat be because of incuriosity to or failure in changing the different combination and unsuitable intestinal micro flora which happens frequently in the second half of pregnancy particularly when complemented with overweight/obesity. In the range of lifestyle-related aspects, probiotics are suggested as part of a balanced diet, low-cost, feasible and potentially impressive strategy to manage this health problem. The objective of this review paper is to review the related studies pursuant to the significance of probiotics and their impression in prohibition and management of GDM. Electronic search was performed in databases, including Scopus, Science direct, PubMed, Cochrane central, Google Scholar, ISC, Magiran, IranMedex, SID, and MedLib. Evidence proposes that manipulation of gut microbiota during pregnancy by certain probiotics in high risk pregnant women may be of pronounced advantage for better metabolic profile of pregnant women and their offspring.  }, Keywords = {gestational diabetes mellitus, metabolic, probiotic, microbiota}, volume = {5}, Number = {2}, pages = {82-97}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-89-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-89-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {SaeidiKia, S and Nejadrahim, E and Nejadrahim, R and Behnamoon, M}, title = {Epidemiology and clinical features of infective endocarditis: A retrospective study of 57 patients in a tertiary university hospital in Iran}, abstract ={Background & Aims:  Infective endocarditis is a life-threatening infectious disease. In order to define the epidemiologic characteristics of infective endocarditis in our region, we studied infective endocarditis cases over a 7-year period in tertiary teaching and referral hospitals. Materials and Methods: Medical records of all hospitalized patients diagnosed with IE at teaching hospitals of Urmia University of Medical Sciences, Iran, from 2009 to 2016, were retrospectively reviewed. Patients who met the modified Duke criteria for definite or possible IE were included. Results: The study included 57 patients (35 males, 22 females; mean age 40 years) who were diagnosed as having definite IE, according to the modified Duke criteria. 15 cases (26.31%) had Rheumatic heart diseases, 12 cases (21.06%) had End Stage Renal Disease, 6 cases (10.53%) had Congenital Heart Disease, 10 cases (17.54%) had Injection Drug User and 14 cases (24.57%) had no significant cardiac disease. The primary clinical manifestations that were observed included 48 cases with fever (84.2%), 35 cases with anemia (61.4%) and 6 cases (11.1%) with altered mental status. Of the total 57 patients, blood cultures were positive in 52 (64.91%) of cases. the leading causative microorganism were Staphylococcus aureus, isolated in 19 cases (51.35%), followed by Gram negative bacilli in 6 cases (16.22%) and Streptococcus spp. in 12 cases (32.43%). In-hospital death 0ccurred in 9 patients (16.7%). Conclusion: Changes in IE profile required continuous epidemiological updates. In this study, IE were most common in men. Staphylococcus aureus and streptococcus spp. Remain the most common etiologic agents. ESRD and IDU was important predisposing factors for IE.}, Keywords = {Infective endocarditis, epidemiology, risk factors}, volume = {5}, Number = {2}, pages = {98-102}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-87-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-87-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Zeinalivand, Selda and Parivar, Kazem and HayatiRoudbari, Nasim}, title = {Follicular growth and atresia and morphometric alteration of uterine tissue following letrozole administration in mature NMRI mice}, abstract ={Background & Aims:  Letrozole, as an aromatase inhibitor drug, is administrated to induce ovulation in individuals with anovulation disorder and, at the same time, it is used to enhance pregnancy success. The current study was designed to investigate the effect of Letrozole on follicular growth/atresia, as well as uterine histology. For this purpose, 15 mature female NMRI mice were assigned into 3 groups (NO=5 in each group): Control, Control sham, which received double distilled water, orally and experimental group received 0.5 mg/kg letrozole, orally. Materials & Methods:  Following 14 days, the animals were euthanized and, the follicular number and percentage of atresia at different stages of growth and the morphometric changes of uterine tissue were analyzed and compared between groups. Results:  The animals in experimental group represented no significant changes in primary, secondary, tertiary follicles, but exhibited a remarkable (p<0.05) reduction in graafian follicles number per two ovaries versus control and control-sham animals. Moreover, the letrozole -received mice exhibited diminished percentages of graafian follicles compared to control and control-sham animals. Finally, the endometrial thickness, as well as endometrial glands distribution per one mm2 of tissue were decreased in experimental group when compared to control and control-sham animals. Conclusion: Letrozole significantly reduces the graafian  follicles atresia and via this mechanism up-regulates the ovulation ratio. However, it is able to prolong uterine development during a menstrual cycle.}, Keywords = {Letrozole, NMRI, Ovary, Ovarian follicles, Uterine}, volume = {5}, Number = {2}, pages = {103-110}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-88-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-88-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Yakhchali, Mohammad and Tehrani, AliAsghar}, title = {The mesenteric lymph nodes pathology by nymph stage of Linguatula serrata in cattle}, abstract ={Linguatula serrata is a cosmopolitan and zoonotic parasite which occurs in carnivores (definitive host) and herbivores animals (intermediate host). Present study was aimed to find out the pathological changes of affected mesenteric lymph nodes (MLNs) by nymph stage of L. serrata in cattle. Carcasses of slaughtered cattle were inspected directly and infected MLNs with L. serrata were collected. Infected MLNs were fixed in 10% formalin and embedded in paraffin. Prepared sections were stained by Hematoxyline-Eosin (H&E) and examined. The MLNs were grossly enlarged, smooth and edematous with cystic areas which nymph stages scattered throughout the lymph nodes. Histopathology changes were included inflammatory reactions brought about by the parasite on the lymph nodes. Reticuloendothelial proliferation resulted in macrophage accumulation, many of these reaction patterns included granulomata. The vascular lesion included prevascular cuffing and mild vaculities. The lymphocytes reduced in number with apoptotic cell death. In view of the consumption of raw or undercooked visceral organs of cattle in the region, a systematic and rigorous inspection of the MLNs in slaughtered cattle would be useful to reduce human infection risk.}, Keywords = {Linguatula serrata, Pathology, Cattle}, volume = {5}, Number = {2}, pages = {111-115}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-83-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-83-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {abbasi, fariba and abbasi, ata and hazrati, zahr}, title = {Histopathologic changes of Non-tumoral Breast Tissue in Patients with Invasive Carcinoma of Breast}, abstract ={Background and aim:  Various studies have shown increased relative risk for breast cancer in patients with different kinds of non-malignant breast diseases. The aim of this study was to evaluate histologic changes in non-tumoral areas of mastectomy specimens of patients with breasts cancer. Methods: 232 consecutive cases of breast carcinoma were enrolled. Histopathology slides of all 232 cases were evaluated by light microscopy for tumor type, size and grade, lympho-vascular invasion (LVI), perineural invasion and also benign changes of nontumoral breast tissue including hyperplasia, inflammation, atypia, adenosis, sclerosing adenosis, apocrine metaplasia, lactating change, calcification, fibrosis and cyst formation. Results: We found no significant association between nontumoral changes and histologic subtypes of the tumor. Our results showed that in cases with apocrine metaplasia the frequencies of lymph node involvement and lymphovascular invasion were significantly lower than cases without apocrine metaplasia (p=0.04 and 0.01, respectively). Apocrine metaplasia was also associated with tumor grade. It was more frequent in low grade tumors than high grade ones (p=0.02). Considering Her2 expression, apocrine metaplasia was seen in only 7% (3/43) of Her2 negative cases in contrast to 29.4% (5/17) in Her2 positive cases (p=0.02). Conclusion: It seems that some of the benign nontumoral changes have a probable relationship with breast carcinoma. So we suggest that follow up of the patients with benign breast changes could be useful in preventing or early diagnosis of breast cancer.}, Keywords = {Breast cancer, non-tumor tissue, benign changes}, volume = {5}, Number = {2}, pages = {116-120}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-84-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-84-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {BagheriHamzyanOlia, jalhe and KhademAnsari, Mohammad Hassan and Rasmi, Yousef and Hasanzadeh-Moghadam, Mahs}, title = {Evaluation of Malondialdehyde Levels and Total Antioxidant Capacity in Patients with Hyperthyroidism}, abstract ={Background & Aims:  Oxidative stress is involved in the pathogenesis of many diseases. Oxidative stress and antioxidant imbalance conditions play a major role in the incidence and development of hyperthyroidism. The aim of this study is to evaluate malondialdehyde (MDA) levels as lipid peroxidation index and total antioxidant capacity (TAC) in hyperthyroid patients compared to control group. Materials and Methods: A case-control study was performed on 35 women with hyperthyroidism and 35 healthy women as control group. Measurement of MDA serum levels was performed by Human Malondealdhyde (MDA) ELIZA KIT from Bioassay Chinese Company by ELIZA method, and serum level measurement was performed by GmbH Zellbio from Zellbio German Company using the ELIZA method. Results: The serum MDA concentration in patients with hyperthyroidism (20.59 ± 2.50 nmol/mL) significantly increased (P = 0.001) compared to the control group (9.94 ± 2.12 nmol/mL), while the serum TAC concentration in the hyperthyroid group (0.769 ± 0.145) significantly decreased (P = 0.001) compared to the control group (1.63 ± 0.286). Conclusion: In this study, total antioxidant capacity in patients with hyperthyroidism was reduced compared to control group, and levels of malondialdehyde increased. These findings indicate that the thyroid gland plays an important role in the production of oxidative stress in disease conditions. Therefore, it is recommended that thyroid hormone disorders and oxidative stress be used in the therapeutic strategies of hyperthyroidism.}, Keywords = {Hyperthyroidism, Malondialdehyde, Total antioxidant capacity, oxidative stress}, volume = {5}, Number = {2}, pages = {121-127}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-86-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-86-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} } @article{ author = {Aghakhani, Nader and Khademvatan, Kamal and Rahbar, Narges and Karimi, Hamideh}, title = {A study on the effect of well- being on myocardial infarction patients’ depression and anxiety in Iran}, abstract ={Background & Aims:  As a major health problem in the world, coronary artery diseases include myocardial infarction (MI) that cause the patients experience mental and emotional problems like depression and anxiety at different periods of their hospitalization time that can affect other medical parameters and increase their needs. Spirituality wellbeing can play an important role in their adapting to some of their mental disorders resulted from illness such as depression and anxiety. Materials and Methods: This descriptive correlational study tried to determine the efficacy of well- being on myocardial infarction patients’ depression and anxiety in in Urmia, Iran. The patients were studied by a questionnaire, consisted of their demographic characteristics and a Palutzian & Ellison spiritual wellbeing scale. Mean scores of anxiety and depression was evaluated by using a HADS questionnaire. All data analyses with a 5% level of statistical significance were conducted through Software SPSS version 18 and descriptive and inferential statistical methods (Chi-square). Results: (29.2%) 46 of patients were female and the rest were male. In addition, (37.7%) of them had other chronic disease and (23.9%) 16 of them had lower levels of depression or anxiety, (53.7%) had a higher level of depression or anxiety disorder (borderline) and finally, (22.4%)  of them had a sever level of depression or anxiety problems. (52.2%) of samples had an average spiritual wellbeing level and the rest had a high spiritual wellbeing level. There was a significant relationship between spiritual wellbeing and level of depression and anxiety with level of education, gender and and occupation.  There was a reverse relationship between the effect of spiritual well- being depression and anxiety in myocardial infarction patients (P = 0.05). Conclusion: Nursing plans based on spirituality wellbeing can be a good solution to decrease depression and anxiety in myocardial infarction patients.}, Keywords = {spiritual well- being, myocardial infarction, depression, anxiety}, volume = {5}, Number = {2}, pages = {128-133}, publisher = {Urmia University of Medical Sciences}, url = {http://ijrabms.umsu.ac.ir/article-1-85-en.html}, eprint = {http://ijrabms.umsu.ac.ir/article-1-85-en.pdf}, journal = {Journal of Research in Applied and Basic Medical Sciences}, issn = {}, eissn = {2717-0098}, year = {2019} }