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:: Volume 6, Issue 3 (July 2020) ::
RABMS 2020, 6(3): 160-166 Back to browse issues page
Serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I multiple myeloma
Zeinab Esmaeilzadeh , Fatemeh Kheradmand , Yousef Rasmi , Mohammad Hassan Khadem-Ansari
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , mhansari1@gmail.com
Abstract:   (87 Views)
Background & Aims: Multiple myeloma (MM) is a type of plasma cell malformation accounting for 10% of the blood cancers with unknown ethiopathology. MM causes changes in inflammatory proteins. The aim of this study was to evaluate the serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I MM.
Materials & Methods: This case-control study was performed on 28 patients with stage I MM including 14 males and 14 females with mean age of 62.11 ± 6.71 years and 40 individuals as controls including 20 males and 20 females with mean age of 60.25 ± 4.81 years matched in both age and sex. Serum concentrations of inflammatory factors including IL-6, TNF-α and YKL-40 were measured using the sandwich Enzyme Linked Immunosorbent Assay (ELISA) method and the data were analyzed using SPSS software.
Results: The serum levels of IL-6 in patients with stage I MM (7.42±5.89 pg/ml) were significantly higher compared to the control group (1.67±1.08 pg/ml); (p< 0.0001). Also, the serum levels of YKL-40 in the patients (45.86 ± 9.14 ng/ml) were significantly higher compared to the control group (35.87 ± 11.2 ng/ml); (p <0.0001). Also, the levels of TNF-α (8.02±1.75 pg/ml) were slightly high compared to the control group (7.77 ± 1.91 pg/ml); (p=0.419).
Conclusion: According to the results in MM, inflammatory proteins such as YKL-40 andIL-6 are the major growth factor of the myeloma cells and help their survival.
Keywords: Multiple myeloma, IL-6, TNF-α, YKL-40
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Type of Study: orginal article | Subject: Special
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Esmaeilzadeh Z, Kheradmand F, Rasmi Y, Khadem-Ansari M H. Serum levels of IL-6, TNF-α, and YKL-40 in patients with stage I multiple myeloma. RABMS. 2020; 6 (3) :160-166
URL: http://ijrabms.umsu.ac.ir/article-1-105-en.html


Volume 6, Issue 3 (July 2020) Back to browse issues page
Journal of Research in Applied and Basic Medical Sciences
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