Investigating the effect of eight weeks of moderate-intensity aerobic exercise and taking curcumin supplement alone and in combination, on leptin levels and hepatic enzymes in older rats

Shirpoor, Minoo; Tofighi, Asghar; Shirpoor, Alireza; Chodari, Leila; Pourjabali, Masoumeh

doi:10.61186/rabms.9.4.263

Volume 9, Issue 4 (10-2023) Journal of Research in Applied and Basic Medical Sciences 2023, 9(4): 263-271 | Back to browse issues page

‎ 10.61186/rabms.9.4.263

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Shirpoor M, Tofighi A, Shirpoor A, Chodari L, Pourjabali M. Investigating the effect of eight weeks of moderate-intensity aerobic exercise and taking curcumin supplement alone and in combination, on leptin levels and hepatic enzymes in older rats. Journal of Research in Applied and Basic Medical Sciences 2023; 9 (4) :263-271
URL: http://ijrabms.umsu.ac.ir/article-1-122-en.html

Investigating the effect of eight weeks of moderate-intensity aerobic exercise and taking curcumin supplement alone and in combination, on leptin levels and hepatic enzymes in older rats

Minoo Shirpoor

, Asghar Tofighi ^*

, Alireza Shirpoor

, Leila Chodari

, Masoumeh Pourjabali

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , a.tofighi@urmia.ac.ir

Abstract: (406 Views)

Background & Aims: Non-alcoholic fatty liver disease is a common health problem in the world, and various studies have shown that the risk of developing the disease increases with age. In this study, we looked at the effects of 8 weeks of moderate-intensity aerobic exercise and curcumin use alone and in combination with each other on leptin and hepatic enzymes levels.
Materials & Methods: 32 male Wistar rats (24-month-old), and 8 male rats with the same breed (4-month-old) were examined in 5 groups (8 rats per group). Two groups were young and old control groups, and three groups included exercise group, curcumin group, and curcumin + exercise group. SPSS18 software and one-way ANOVA method and Tukey's post hoc test were utilized and 0.05> α was considered statistically significant.
Results: 8 weeks of aerobic exercise did not have a significant reduction in the level of leptin and hepatic enzymes, and 8 weeks of curcumin significantly reduced leptin levels and did not significantly reduce hepatic enzymes. Combined aerobic exercise and curcumin significantly reduced leptin and hepatic enzymes.
Conclusion: Concomitant use of curcumin with moderate-intensity aerobic exercise can have positive effects on reducing leptin levels and hepatic enzymes in patients with non-alcoholic fatty liver disease.

Keywords: Aerobic exercise, curcumin, non-alcoholic fatty liver, aging, leptin, hepatic enzyme

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Type of Study: orginal article | Subject: Special

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