Microbiological Profile and Antibiotic Resistance Pattern of Uropathogens in Diabetic and Non-Diabetic Patients

Mohammadshahi, Jafar; Iranparvar, Manuchehr; Habibzadeh, Shahram; Teimourpour, Roghayeh

Volume 6, Issue 4 (12-2020) Journal of Research in Applied and Basic Medical Sciences 2020, 6(4): 216-232 | Back to browse issues page

Mendeley

Zotero

RefWorks

Mohammadshahi J, Iranparvar M, Habibzadeh S, Teimourpour R. Microbiological Profile and Antibiotic Resistance Pattern of Uropathogens in Diabetic and Non-Diabetic Patients. Journal of Research in Applied and Basic Medical Sciences 2020; 6 (4) :216-232
URL: http://ijrabms.umsu.ac.ir/article-1-132-en.html

Microbiological Profile and Antibiotic Resistance Pattern of Uropathogens in Diabetic and Non-Diabetic Patients

Jafar Mohammadshahi

, Manuchehr Iranparvar

, Shahram Habibzadeh

, Roghayeh Teimourpour ^*

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran , r.teymourpour@gmail.com

Abstract: (2269 Views)

Background & Aims: Urinary tract infection (UTI) is one of the most common human infections which is more prevalent especially in patients with diabetes mellitus. The aim of this study was to compare the uropathogens isolated from the urine culture of diabetic and non-diabetic patients and their antibiotic resistance pattern in patients admitted to Imam Khomeini Hospital in Ardabil from 2012 to 2013.
Materials & Methods: In this descriptive cross-sectional study, the medical records of all patients admitted to Imam Khomeini University Hospital in Ardabil province from the beginning of 2012 to the end of 2014 were reviewed and the required information including age, sex, or the absence of diabetes was recorded.
Results: E. coli was the most common uropathogens isolated from both diabetic (58.1%) and non-diabetic (53.6%) patients followed by yeast (19.4%) in both groups. Other common organisms in diabetic and non-diabetic patients were Staphylococcus aureus (8.4%) and coagulase negative Staphylococcus (7.1%), respectively. Among diabetic patients, E. coli had the highest sensitivity to polymyxin (100%), tetracycline (100%), and amikacin (88.9%). In non-diabetic patients, E. coli had the highest sensitivity to amikacin (90.4%), nitrofurantoin (86%), cefoxitin (85.3%), and gentamicin (82.1%).
Conclusion: Our findings indicated that susceptibility profiles of uropathogens are different in diabetic and non-diabetic individuals, therefore, empirical treatment for diabetic and non-diabetic patients will be different.

Keywords: hospital, antibiotic, Escherichia coli, Staphylococcus aureus

Full-Text [PDF 410 kb] (1092 Downloads)

Type of Study: orginal article | Subject: General

References

1. Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol 2015;13(5):269. [DOI:10.1038/nrmicro3432] [PMID] [PMCID]

2. Sobel JD, Fisher JF, Kauffman CA, Newman CA. Candida urinary tract infections-epidemiology. Clin Infect Dis 2011;52(suppl_6):S433-S6. [DOI:10.1093/cid/cir109] [PMID]

3. Mnif MF, Kamoun M, Kacem FH, Bouaziz Z, Charfi N, Mnif F, et al. Complicated urinary tract infections associated with diabetes mellitus: Pathogenesis, diagnosis and management. Indian J Endocrinol Metab 2013;17(3):442. [DOI:10.4103/2230-8210.111637] [PMID] [PMCID]

4. Kofteridis DP, Papadimitraki E, Mantadakis E, Maraki S, Papadakis JA, Tzifa G, et al. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc 2009;57(11):2125-8. [DOI:10.1111/j.1532-5415.2009.02550.x] [PMID]

5. Hirji I, Guo Z, Andersson SW, Hammar N, Gomez-Caminero A. Incidence of urinary tract infection among patients with type 2 diabetes in the UK General Practice Research Database (GPRD). J Diabetes Complications 2012;26(6):513-6. https://doi.org/10.1016/j.jdiacomp.2012.06.012 [DOI:10.1016/j.jdiacomp.2012.06.008]

6. Yu S, Fu AZ, Qiu Y, Engel SS, Shankar R, Brodovicz KG, et al. Disease burden of urinary tract infections among type 2 diabetes mellitus patients in the US. J Diabetes Complications2014;28(5):621-6. [DOI:10.1016/j.jdiacomp.2014.03.012] [PMID]

7. Geerlings SE, Brouwer EC, Van Kessel KC, Gaastra W, Stolk RP, Hoepelman AI. Cytokine secretion is impaired in women with diabetes mellitus. Eur J Clin Invest 2000;30(11):995-1001. [DOI:10.1046/j.1365-2362.2000.00745.x] [PMID]

8. Navidinia M, Peerayeh SN, Fallah F, Bakhshi B, Sajadinia RS. Phylogenetic grouping and pathotypic comparison of urine and fecal Escherichia coli isolates from children with urinary tract infection. Braz J Microbiol 2014;45(2):509-14. [DOI:10.1590/S1517-83822014000200019] [PMID] [PMCID]

9. Shahin Najar Peerayeh MN, Fatemeh Fallah, Bita Bakhshi , Jamshid Jamali. Pathogenicity determinants and epidemiology of uropathogenic E. coli (UPEC) strains isolated from children with urinary tract infection (UTI) to define distinct pathotypes. Biomed Res 2018;29(10):2035-43. [DOI:10.4066/biomedicalresearch.29-17-1591]

10. Tandogdu Z, Wagenlehner FM. Global epidemiology of urinary tract infections. Curr Opin Infect Dis 2016;29(1):73-9. [DOI:10.1097/QCO.0000000000000228] [PMID]

11. Isapour A, Asadian L, Ashbin F, Akha O. Prevalence of asymptomatic urinary tract infection in diabetic patients. J Mazandaran Univ Med Sci 2015;25(125):95-101. [Google Scholar]

12. Shah BR, Hux JE. Quantifying the risk of infectious diseases for people with diabetes. Diabetes care 2003;26(2):510-3. [DOI:10.2337/diacare.26.2.510] [PMID]

13. Lim J-H, Cho J-H, Lee J-H, Park Y-J, Jin S, Park G-Y, et al.. Risk factors for recurrent urinary tract infection in kidney transplant recipients. Transplant Proc 2013 ;45(4):1584-9.14. [DOI:10.1016/j.transproceed.2012.12.011] [PMID]

14. Geerlings SE, Stolk RP, Camps M, Netten PM, Collet TJ, Hoepelman A, et al. Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes care 2000;23(12):1737-41. [DOI:10.2337/diacare.23.12.1737] [PMID]

15. Nitzan O, Elias M, Chazan B, Saliba W. Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management. Diabetes Metab Syndr Obes 2015; 8:129-36. [DOI:10.2147/DMSO.S51792] [PMID] [PMCID]

16. Brown JS, Wessells H, Chancellor MB, Howards SS, Stamm WE, Stapleton AE, et al. Urologic complications of diabetes. Diabetes care 2005;28(1):177-85. [DOI:10.2337/diacare.28.1.177] [PMID]

17. Fakour F, Falahati M, Zaini F, Mousavi Nasab N. A survey of candiduria in diabetic patients of Zanjan, 2001-2002. Razi Journal of Medical Sciences 2004;11(41):453-61. [Google Scholar]

18. Vasudevan R. Urinary tract infection: an overview of the infection and the associated risk factors. J Microbiol Exp 2014;1(2):00008. [DOI:10.15406/jmen.2014.01.00008]

19. Scholes D, Hooton TM, Roberts PL, Gupta K, Stapleton AE, Stamm WE. Risk factors associated with acute pyelonephritis in healthy women. Ann Intern Med 2005;142(1):20. [DOI:10.7326/0003-4819-142-1-200501040-00008] [PMID] [PMCID]

20. Benfield T, Jensen J, Nordestgaard B. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007;50(3):549-54. [DOI:10.1007/s00125-006-0570-3] [PMID]

21. Wen S-C, Juan Y-S, Wang C-J, Chang K, Shih M-CP, Shen J-T, et al. Emphysematous prostatic abscess: case series study and review. Int J Infect Dis 2012;16(5):e344-e9. [DOI:10.1016/j.ijid.2012.01.002] [PMID]