Volume 6, Issue 4 (12-2020)                   RABMS 2020, 6(4): 233-240 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alizadeh Chamkhaleh M, Gandomi-Mohammadabadi A, Ghoohestani F, Olamaeiam F, Golfiroozi S, Abbasi M A. Neutrophil to Lymphocyte Ratio as a Predictive Factor for Evaluation of Outcome in Critically Ill Patients. RABMS. 2020; 6 (4) :233-240
URL: http://ijrabms.umsu.ac.ir/article-1-136-en.html
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , maryam.alizadeh9655@gmail.com
Abstract:   (1007 Views)
Background & Aims:  Morbidity and mortality are higher in intensive care units (ICU). In this study hematological indexes such as NLR (Neutrophil to lymphocyte ratio) and PLR (platelet to lymphocyte ratio) were investigated in the ICU patients.
Materials & Methods: We did a retrospective study on ICU patients older than 18 years between June 2019 and July 2019. We gathered medical and laboratory data in the first 24 hours of ICU hospitalization and analyzed them. There were two groups of survived and un-survived. The primary outcome measure was death in ICU.
Results: We included 194 patients whose mean age was 66.7 ± 20.1 years, and 105(54%) patients were male. 76 (39%) patients were non-survivors. Non-survivors had significantly higher NLR value (mean, 16 ± 15.1) than the survivors (mean, 10.5 ± 14, p = .015). The PLR of survivors and non-survivors was 240.3 ± 156.7 and 320.3 ± 269.1, respectively. PLR was not different between groups (p >0.05).
Conclusion: These results suggest that NLR at admission is associated with higher mortality in the ICU among critically ill patients over 18 years old. Therefore, NLR at admission may be an alternative indicator of disease severity.
Full-Text [PDF 290 kb]   (607 Downloads)    
Type of Study: orginal article | Subject: General

References
1. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009;302(21):2323-9. [DOI:10.1001/jama.2009.1754] [PMID]
2. Mayr VD, Dunser MW, Greil V, Jochberger S, Luckner G, Ulmer H, et al. Causes of death and determinants of outcome in critically ill patients. Crit Care 2006;10(6):R154. [DOI:10.1186/cc5086] [PMID] [PMCID]
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29(7):1303-10. [DOI:10.1097/00003246-200107000-00002] [PMID]
4. Hwang SY, Shin TG, Jo IJ, Jeon K, Suh GY, Lee TR, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. Am J Emerg Med 2017;35(2):234-9. [DOI:10.1016/j.ajem.2016.10.055] [PMID]
5. Song H, Kim HJ, Park KN, Kim SH, Oh SH, Youn CS. Neutrophil to lymphocyte ratio is associated with in-hospital mortality in older adults admitted to the emergency department. Am J Emerg Med.2020 ;S0735-6757(20)30044-9. [Google Scholar]
6. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11(1):55-9. [DOI:10.1586/erc.12.159] [PMID]
7. Salciccioli JD, Marshall DC, Pimentel MA, Santos MD, Pollard T, Celi LA, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Crit Care 2015;19:13. [DOI:10.1186/s13054-014-0731-6] [PMID] [PMCID]
8. Yoldas H, Karagoz I, Ogun MN, Velioglu Y, Yildiz I, Bilgi M, et al. Novel Mortality Markers for Critically Ill Patients. J Intensive Care Med 2020;35(4):383-5. [DOI:10.1177/0885066617753389] [PMID]
9. Kwon H-C, Kim SH, Oh SY, Lee S, Lee JH, Choi H-J, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17(3):216-22. [DOI:10.3109/1354750X.2012.656705] [PMID]
10. Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 2011;47(17):2633-41. [DOI:10.1016/j.ejca.2011.03.028] [PMID]
11. Liu X, Shen Y, Wang H, Ge Q, Fei A, Pan S. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study. Mediators Inflamm 2016;2016:8191254. [DOI:10.1155/2016/8191254] [PMID] [PMCID]
12. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102(6):653-7. [DOI:10.1016/j.amjcard.2008.05.006] [PMID]
13. Zahorec R. Ratio of neutrophil to lymphocyte counts-Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5-14. [Google Scholar]
14. O'Mahony JB, Palder SB, Wood JJ, McIrvine A, Rodrick ML, Demling RH, et al. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984;24(10):869-75. [DOI:10.1097/00005373-198410000-00001] [PMID]
15. Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002;18(6):487-94. [DOI:10.1097/00024382-200212000-00001] [PMID]
16. Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A. Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care 2012;16(1):R12. [DOI:10.1186/cc11157] [PMID] [PMCID]
17. Menges T, Engel J, Welters I, Wagner RM, Little S, Ruwoldt R, et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med 1999;27(4):733-40. [DOI:10.1097/00003246-199904000-00026] [PMID]
18. Azab B, Jaglall N, Atallah JP, Lamet A, Raja-Surya V, Farah B, et al. Neutrophil-Lymphocyte Ratio as a Predictor of Adverse outcomes of Acute Pancreatitis. Pancreatology 2011;11(4):445-52. [DOI:10.1159/000331494] [PMID]
19. Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, et al. A High Preoperative Neutrophil-to-lymphocyte Ratio Is Associated with Poor Survival in Patients with Colorectal Cancer. Anticancer Res 2013;33:3291-4. [Google Scholar]
20. Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T, et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 2012;19(1):217-24. [DOI:10.1245/s10434-011-1814-0] [PMID]
21. Mano Y, Shirabe K, Yamashita Y, Harimoto N, Tsujita E, Takeishi K, et al. Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg 2013;258(2):301-5. [DOI:10.1097/SLA.0b013e318297ad6b] [PMID]
22. Shafique K, Proctor MJ, McMillan DC, Qureshi K, Leung H, Morrison DS. Systemic inflammation and survival of patients with prostate cancer: evidence from the Glasgow Inflammation Outcome Study. Prostate Cancer Prostatic Dis 2012;15(2):195-201. [DOI:10.1038/pcan.2011.60] [PMID]
23. Zhao W, Wu Z, Li Y, Jia H, Chen M, Gu X, et al. Pretreatment neutrophil-to-lymphocyte ratio and its dynamic changes are associated with the overall survival in advanced cancer patients undergoing palliative care. Sci Rep 2016;6:31394. [DOI:10.1038/srep31394] [PMID] [PMCID]
24. Otunctemur A, Dursun M, Besiroglu H, Ozer K, Horsanali O, Ozbek E. Clinical Significance of Preoperative Neutrophil - to - Lymphocyte Ratio in Renal Cell Carcinoma. Int Braz J Urol 2016;42(4):678-84. [DOI:10.1590/S1677-5538.IBJU.2015.0397] [PMID] [PMCID]
25. Yapici O, Berk H, Oztoprak N, Seyman D, Tahmaz A, Merdin A. Can Ratio of Neutrophil-to-Lymphocyte Count and Erythrocyte Sedimentation Rate in Diabetic Foot Infecti on Predict Osteomyelitis and/or Amputation? Hematol Rep 2017;9(1):6981. [DOI:10.4081/hr.2017.6981] [PMID] [PMCID]
26. Forget P, Khalifa C, Defour JP, Latinne D, Van Pel MC, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes 2017;10(1):12. [DOI:10.1186/s13104-016-2335-5] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Journal of Research in Applied and Basic Medical Sciences

Designed & Developed by : Yektaweb