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Nazemi salman B, Bakhtiary A, Taheri S. Effectiveness of Silver Diamine Fluoride compared with Sodium Fluoride Varnish on Oral Saliva pH in the Children with Sever-Early Childhood Caries (S-ECC). Journal of Research in Applied and Basic Medical Sciences 2022; 8 (4) :196-203
URL: http://ijrabms.umsu.ac.ir/article-1-202-en.html
PhD candidate, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , Solmaz.taheri.1990@gmail.com
Abstract:   (885 Views)
Background & Aims:  Colorless Silver Diamine Fluoride (SDF) solution is effective in increasing the remineralization of hard tooth tissue, and the silver ion in it has antibacterial properties. The aim of this study was to compare the effect of Sodium Fluoride (NaF) varnish with SDF on oral saliva pH in children with premature dental caries.
Materials & Methods:  In this clinical trial study, 25 children with the age group of 3-6 years old were randomly selected, and then randomly divided to two groups of receiving NaF and receiving SDF. The rate of salivary pH change in both study groups was measured and recorded before treatment (baseline time), 5, 10, 20, and 30 minutes after treatment, using digital pH meter. The results were evaluated using repeated measures and independent t-test at a significance level of 0.05%.
Results:  The mean salivary pH level of the SDF group in the fifth (p = 0.018), tenth (p = 0.022), and twentieth (p = 0.039) minutes after treatment was significantly higher than it in the NaF group. In the SDF group, saliva pH at 5 (p = 0.001), 10 (p <0.001), 20 (p <0.001) and 30 minutes (p = 0.002) was significantly higher than the baseline time.
Conclusion:  The saliva pH of children increased significantly after using SDF compared to NaF. Due to the other positive effects of SDF in preventing caries compared to NaF, this substance is recommended for oral pH control in ECC and S-ECC treatment plans, especially in the cases where anesthesia is not possible.
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Type of Study: orginal article | Subject: Special

1. De Mello Vieira AE, Botazzo Delbem AC, Sassaki KT, Rodrigues E, Cury JA, Cunha RF. Fluoride dose response in pH-cycling models using bovine enamel. Caries Res 2005;39(6):514-20. [DOI:10.1159/000088189] [PMID]
2. Emadian M, Malekzadeh Shafaroudi A, Mesgarani A, Afkhaminia F, Nahvi A. Mother's Knowledge Regarding Oral Health among Their Preschool Children. Int J Pediatr 2020;8(8):11681-9. [Google Scholar]
3. Burke FJT. From Extension for Prevention to Prevention of Extension: (Minimal Intervention Dentistry). Dent Update 2003;30(9):492-502. [DOI:10.12968/denu.2003.30.9.492] [PMID]
4. Eidelman AI, Schanler RJ. Breastfeeding and the use of human milk. Pediatrics 2012;129(3):e827-e41. [DOI:10.1542/peds.2011-3552] [PMID]
5. Apriani A, Widyarman A, Budiyanti E, Roeslan B. Caries activity and ph level changes after fluoride varnish and casein phosphopeptides-amorphous calcium phosphate application on children's saliva. Contemp Clin Dent 2020;11(2):126-30. [DOI:10.4103/ccd.ccd_167_20] [PMID] [PMCID]
6. Sköld UM, Petersson LG, Birkhed D, Norlund A. Cost-analysis of school-based fluoride varnish and fluoride rinsing programs. Acta Odontol Scand 2008;66(5):286-92. [DOI:10.1080/00016350802293978] [PMID]
7. dos Santos APP, Nadanovsky P, de Oliveira BH. A systematic review and meta‐analysis of the effects of fluoride toothpastes on the prevention of dental caries in the primary dentition of preschool children. Community Dent Oral Epidemiol 2013;41(1):1-12. [DOI:10.1111/j.1600-0528.2012.00708.x] [PMID]
8. Duckworth RM, Knoop DTM, Stephen KW. Effect of mouthrinsing after toothbrushing with a fluoride dentifrice on human salivary fluoride levels. Caries Res 1991;25(4):287-91. [DOI:10.1159/000261378] [PMID]
9. Hicks J, Wild T, Flaitz CM, Seybold S. Fluoride varnishes and caries development in primary tooth enamel: an in vitro study. ASDC J Dent Child 2001;68(5-6):300,304-10. [Google Scholar]
10. Duckworth RM, Morgan SN. Oral fluoride retention after use of fluoride dentifrices. Caries Res 1991;25(2):123-9. [DOI:10.1159/000261354] [PMID]
11. Mei ML, Chu CH, Lo ECM, Samaranayake LP. Fluoride and silver concentrations of silver diammine fluoride solutions for dental use. Int J Paediatr Dent 2013;23(4):279-85. [DOI:10.1111/ipd.12005] [PMID]
12. Chu CH, Mei ML, Lo EC. Use of fluorides in dental caries management. Gen Dent 2010;58(1):35-7 [Google Scholar]
13. Pinkham JR, Casamassimo PS, Fields HW, McTigue DJ, Nowak A. Pediatric dentistry. Infancy through Adolesc 2005;4. [URL]
14. McDonald RE, Avery DR, Dean JA. Dentistry for the child and adolescent 9th ed. St Louis Mosby co. Published online 2011:28-43. [URL]
15. Miller EK, Vann WF. The use of fluoride varnish in children: A critical review with treatment recommendations. J Clin Pediatr Dent 2008;32(4):259-64. [DOI:10.17796/jcpd.32.4.a7516vj8762687v5] [PMID]
16. Pinkham JR, Casamassimo P, Fields H, McTigue D, Nowak A. Infancy through adolescence 4th ed. Pediatr Dent. Published online 2005:594-5. [URL]
17. McDonald RE, Avery DR, Dean J. Dentistry for the child and adolescent. St Louis Mosby. Published online 2008:11-2. [URL]
18. Chen A, Cho M, Kichler S. Silver Diamine Fluoride : An Alternative to Topical Fluorides. J Can Dent Assoc 2012;20(10):1-14.
19. Delbem ACB, Bergamaschi M, Sassaki KT, Cunha RF. Effect of fluoridated varnish and silver diamine fluoride solution on enamel demineralization: pH-cycling study. J Appl Oral Sci 2006;14(2):88-92. [DOI:10.1590/S1678-77572006000200005] [PMID] [PMCID]
20. Chu CH, Lo ECM. Microhardness of dentine in primary teeth after topical fluoride applications. J Dent 2008;36(6):387-91. [DOI:10.1016/j.jdent.2008.02.013] [PMID]
21. Lo ECM, Chu CH, Lin HC. A community-based caries control program for pre-school children using topical fluorides: 18-month results. J Dent Res 2001;80(12):2071-4. [DOI:10.1177/00220345010800120901] [PMID]
22. Chu CH, Lo ECM. Promoting caries arrest in children with silver diamine fluoride: a review. Oral Health Prev Dent 2008;6(4):315-21. [Google Scholar]
23. Lou YL, Botelho MG, Darvell BW. Reaction of silver diamine fluoride with hydroxyapatite and protein. J Dent 2011;39(9):612-8. [DOI:10.1016/j.jdent.2011.06.008] [PMID]
24. Gao SS, Zhao IS, Hiraishi N, et al. Clinical Trials of Silver Diamine Fluoride in Arresting Caries among Children: A Systematic Review. JDR Clin Trans Res 2016;1(3):201-10. [DOI:10.1177/2380084416661474] [PMID]
25. Llodra JC, Rodriguez A, Ferrer B, Menardia V, Ramos T, Morato M. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. J Dent Res 2005;84(8):721-4. [DOI:10.1177/154405910508400807] [PMID]
26. Salehzadeh Esfahani K, Mazaheri R, Pishevar L. Effects of Treatment with Various Remineralizing Agents on the Microhardness of Demineralized Enamel Surface. J Dent Res Dent Clin Dent Prospects 2015;9(4):239-45. [DOI:10.15171/joddd.2015.043] [PMID] [PMCID]
27. Gao SS, Zhang S, Mei ML, Lo EC-M, Chu C-H. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment-a systematic review. BMC Oral Health 2016;16(1):12. [DOI:10.1186/s12903-016-0171-6] [PMID] [PMCID]
28. Kazemi Karyani A, Karmi Matin B, Soltani S, et al. Socioeconomic gradient in physical activity: Findings from the PERSIAN cohort study. BMC Public Health 2019;19(1):1-11. [DOI:10.1186/s12889-019-7715-z] [PMID] [PMCID]
29. Divaris K, Preisser JS, Slade GD. Surface-specific efficacy of fluoride varnish in caries prevention in the primary dentition: results of a community randomized clinical trial. Caries Res 2013;47(1):78-87. [DOI:10.1159/000344015] [PMID]
30. Chhabra N, Chhabra A. Enhanced Remineralisation of Tooth Enamel Using Casein Phosphopeptide-Amorphous Calcium Phosphate Complex: A Review. Int J Clin Prev Dent 2018;14(1):1-10. [DOI:10.15236/ijcpd.2018.14.1.1]
31. Shimizu A, Kawagoe M. A clinical study of effect of diammine silver fluoride on recurrement caries. J Osaka Univ Dent Sch 1976;16:103-9.
32. Bedi R S-IJ. Oral health care in disadvantaged communities, London: FDI world press. London FDI World. Published online 1999.
33. Li Y, Liu Y, Psoter WJ, et al. Assessment of the Silver Penetration and Distribution in Carious Lesions of Deciduous Teeth Treated with Silver Diamine Fluoride. Caries Res 2019;53(4):431-40. [DOI:10.1159/000496210] [PMID]
34. Suzuki T, Nishida M, Sobue S, Moriwaki Y. Effects of diammine silver fluoride on tooth enamel. J Osaka Univ Dent Sch 1974;14:61-72. [PMID]
35. Santos L de M, dos Reis JIL, de Medeiros MP, Ramos SM, de Araújo JM. In vitro evaluation of fluoride products in the development of carious lesions in deciduous teeth. Braz Oral Res 2009;23(3):296-301. [DOI:10.1590/S1806-83242009000300012] [PMID]
36. Chu CH, Lo EC, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. J Dent Res 2002;81(11):767-770. https://doi.org/10.1177/0810767 [DOI:10.1177/154405910208101109] [PMID]
37. Li R, Lo ECM, Liu BY, Wong MCM, Chu CH. Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. J Dent 2016;51:15-20. [DOI:10.1016/j.jdent.2016.05.005] [PMID]
38. Rosenblatt A, Stamford TCM, Niederman R. Silver diamine fluoride: A caries "silver-fluoride bullet." J Dent Res 2009;88(2):116-25. [DOI:10.1177/0022034508329406] [PMID]
39. Mei ML, Ito L, Cao Y, Lo EC, Li QL, Chu CH. An ex vivo study of arrested primary teeth caries with silver diamine fluoride therapy. J Dent 2014;42(4):395-402. [DOI:10.1016/j.jdent.2013.12.007] [PMID]

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