Volume 10, Issue 4 (11-2024)
Journal of Research in Applied and Basic Medical Sciences 2024, 10(4): 324-328 |
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Bhatt U, Shah H. Chronic myeloid leukemia in an asymptomatic young patient: a rare case report. Journal of Research in Applied and Basic Medical Sciences 2024; 10 (4) :324-328
URL: http://ijrabms.umsu.ac.ir/article-1-331-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-331-en.html
Department of Pathology, Medical College and SSG Hospital , Baroda, India , urjabhatt2@gmail.com
Abstract: (249 Views)
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm arising from the neoplastic transformation of pluripotent stem cells and is consistently associated with the BCR-ABL fusion gene located on the Philadelphia chromosome. It accounts for approximately 15% of all cases of leukemia in adults. Its annual incidence is 1-2 cases per 100,000 individuals. It is uncommon in children, and less than 3% of all patients with CML are younger than 20 years. Here, we report an uncommon case of CML in a young male presenting without symptoms.
The case was a 19-year-old male who came for a physical fitness checkup. He did not have any presenting symptoms or comorbidities. He arrived at SSG Hospital, where his blood sample was taken and sent to the Hematology Laboratory, Pathology Department, Medical College of Baroda, due to a persistently high leucocyte count for 1 month. On examination, the patient was conscious, oriented, and vitally stable. There was no pallor, icterus, pedal edema, or skin rash. There were no complaints of weight loss, anorexia, abdominal pain, or coughing. Cardiovascular and neurological examinations were normal. On abdominal examination, massive grade 4 splenomegaly was found. In view of the high WBC count and massive splenomegaly, he was advised to undergo cytogenetic examination to confirm or rule out the possibility of CML.
The case was a 19-year-old male who came for a physical fitness checkup. He did not have any presenting symptoms or comorbidities. He arrived at SSG Hospital, where his blood sample was taken and sent to the Hematology Laboratory, Pathology Department, Medical College of Baroda, due to a persistently high leucocyte count for 1 month. On examination, the patient was conscious, oriented, and vitally stable. There was no pallor, icterus, pedal edema, or skin rash. There were no complaints of weight loss, anorexia, abdominal pain, or coughing. Cardiovascular and neurological examinations were normal. On abdominal examination, massive grade 4 splenomegaly was found. In view of the high WBC count and massive splenomegaly, he was advised to undergo cytogenetic examination to confirm or rule out the possibility of CML.
Keywords: Asymptomatic, BCR-ABL fusion gene, Chronic myeloid leukemia, Philadelphia chromosome, Young adult
Type of Study: case report |
Subject:
Hematology
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