Volume 11, Issue 3 (8-2025)
Journal of Research in Applied and Basic Medical Sciences 2025, 11(3): 312-316 |
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Ethics code: A/206/REB-Comm(FP)/RIMS/2015/201/07/2023
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Leishangthem J D, Irungbam D, rajkumari K. Amniotic Band Syndrome: A Case Series. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (3) :312-316
URL: http://ijrabms.umsu.ac.ir/article-1-373-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-373-en.html
Department of Anatomy, Regional Institute of Medical Sciences, Imphal, India , leishangthem.joshila3089@gmail.com
Abstract: (36 Views)
Amniotic band syndrome is an uncommon condition associated with multiple congenital anomalies. It affects about 1 in 1,200 to 1 in
15,000 live births and is often a consequence of fibrotic amniotic bands extending from the placenta to the fetus. It is associated with
various fetal structural anomalies, notably craniofacial and limb anomalies. Six fetuses were collected from the Department of
Obstetrics and Gynecology, RIMS, Imphal, after obtaining permission from the concerned authorities and parents. The fetuses were
examined externally, dissected, and radiological examination was done wherever appropriate. On examination, Fetus 1 had
encephalocele in the frontal region, cleft palate, malformed nose, abdominoschisis, bilateral clubfoot, and amputation of the right
index, middle, and ring fingers. Fetus 2 had amputation of the left hand associated with left-sided gastroschisis. Fetus 3 had
amputation of the right 1 st , 2 nd , 3 rd, and 4 th toes. Fetus 4 had an anterior abdominal wall defect associated with amputation of the right
2 nd , 3 rd , and 4 th fingers. Fetuses 5 and 6 showed no brain tissue in the area of the defect. The amniotic membrane was attached to the
scalp in both cases. Amniotic band syndrome is a sporadic condition that can result in various degrees of limb defects and major
organ malformations. Amniotic band syndrome should be considered in any fetus presenting with congenital anomalies, especially
those involving defects of the extremities and/ or body wall.
15,000 live births and is often a consequence of fibrotic amniotic bands extending from the placenta to the fetus. It is associated with
various fetal structural anomalies, notably craniofacial and limb anomalies. Six fetuses were collected from the Department of
Obstetrics and Gynecology, RIMS, Imphal, after obtaining permission from the concerned authorities and parents. The fetuses were
examined externally, dissected, and radiological examination was done wherever appropriate. On examination, Fetus 1 had
encephalocele in the frontal region, cleft palate, malformed nose, abdominoschisis, bilateral clubfoot, and amputation of the right
index, middle, and ring fingers. Fetus 2 had amputation of the left hand associated with left-sided gastroschisis. Fetus 3 had
amputation of the right 1 st , 2 nd , 3 rd, and 4 th toes. Fetus 4 had an anterior abdominal wall defect associated with amputation of the right
2 nd , 3 rd , and 4 th fingers. Fetuses 5 and 6 showed no brain tissue in the area of the defect. The amniotic membrane was attached to the
scalp in both cases. Amniotic band syndrome is a sporadic condition that can result in various degrees of limb defects and major
organ malformations. Amniotic band syndrome should be considered in any fetus presenting with congenital anomalies, especially
those involving defects of the extremities and/ or body wall.
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