Volume 11, Issue 2 (4-2025)
Journal of Research in Applied and Basic Medical Sciences 2025, 11(2): 147-154 |
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Abdrabo A, Omer S, Eldaif W. Impact of type 2 diabetes mellitus on semen quality in Sudanese males: a case-control study. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (2) :147-154
URL: http://ijrabms.umsu.ac.ir/article-1-389-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-389-en.html
Department of Nursing, Clinical Biochemistry, College of Applied Medical Sciences, Buraydah Private Colleges, Saudi Arabia. , abdrabokarim@gmail.com
Abstract: (305 Views)
Background & Aims: Infertility affects a significant proportion of couples, with male factors contributing to many cases. Diabetes mellitus (DM) is a major risk factor for male infertility, potentially affecting semen quality. To evaluate the impact of type 2 diabetes mellitus on semen parameters in Sudanese males.
Materials & Methods: The study included 600 Sudanese men, consisting of 300 individuals diagnosed with type 2 diabetes mellitus (T2DM) and 300 non-diabetic individuals serving as controls. Anthropometric measurements and semen analysis, including semen volume, sperm count, motility, and morphology, were assessed.
Results: The mean ages of the diabetic and non-diabetic groups were 35 ± 1.5 years and 34 ± 1.7 years, respectively (P = 0.60). Significant differences were observed in body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR). Diabetic patients had a higher BMI (31.5 ± 0.5 kg/m²) compared to non-diabetic controls (24.0 ± 0.3 kg/m², P = 0.01). Semen volume was significantly lower in diabetic patients (2.46 ± 1.18 mL) than in non-diabetic controls (2.75 ± 1.19 mL, P = 0.047). Sperm count showed no significant difference (67.3 ± 33.1 million/mL in diabetics vs. 68.3 ± 40 million/mL in controls, P = 0.3). However, 30% of diabetic patients exhibited abnormal sperm motility compared to 20% in controls, with odds ratios (ORs) of 1.7 for motility and 5.1 for abnormal morphology.
Conclusion: The study highlights significant impairments in semen quality among Sudanese males with type 2 diabetes mellitus, emphasizing the need for further research into the underlying mechanisms and implications for male fertility.
Materials & Methods: The study included 600 Sudanese men, consisting of 300 individuals diagnosed with type 2 diabetes mellitus (T2DM) and 300 non-diabetic individuals serving as controls. Anthropometric measurements and semen analysis, including semen volume, sperm count, motility, and morphology, were assessed.
Results: The mean ages of the diabetic and non-diabetic groups were 35 ± 1.5 years and 34 ± 1.7 years, respectively (P = 0.60). Significant differences were observed in body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR). Diabetic patients had a higher BMI (31.5 ± 0.5 kg/m²) compared to non-diabetic controls (24.0 ± 0.3 kg/m², P = 0.01). Semen volume was significantly lower in diabetic patients (2.46 ± 1.18 mL) than in non-diabetic controls (2.75 ± 1.19 mL, P = 0.047). Sperm count showed no significant difference (67.3 ± 33.1 million/mL in diabetics vs. 68.3 ± 40 million/mL in controls, P = 0.3). However, 30% of diabetic patients exhibited abnormal sperm motility compared to 20% in controls, with odds ratios (ORs) of 1.7 for motility and 5.1 for abnormal morphology.
Conclusion: The study highlights significant impairments in semen quality among Sudanese males with type 2 diabetes mellitus, emphasizing the need for further research into the underlying mechanisms and implications for male fertility.
Keywords: Male infertility, Semen quality, Sperm morphology, Sperm motility, Type 2 diabetes mellitus
Type of Study: orginal article |
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