Volume 11, Issue 3 (8-2025)
Journal of Research in Applied and Basic Medical Sciences 2025, 11(3): 285-289 |
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Ethics code: MC-421 (GMCS-2020)
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Lone P A, Khan M A, Shah B A. Nandrolone Decanoate-Induced Prostatic Hyperplasia: A Histopathological Study. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (3) :285-289
URL: http://ijrabms.umsu.ac.ir/article-1-427-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-427-en.html
Department of Anatomy, Govt. Medical College, Anantnag, Jammu and Kashmir, India , PARVAIZGULL01@GMAIL.COM
Abstract: (41 Views)
Background Nandrolone decanoate is a widely abused synthetic anabolic-androgenic steroid associated with prostate disorders in users. This study quantitatively analyzes its morphometric and histopathological effects on rat prostate tissue.
Methods Twenty male Wistar albino rats were divided into control (Group A, n=5) and treatment (Group B, n=15) groups. Group A received weekly intramuscular injections of peanut oil vehicle, while Group B received nandrolone decanoate (10 mg/kg body weight) weekly for 8 weeks. Body weights were recorded weekly. After euthanasia, prostate tissues were weighed and processed for histological examination using hematoxylin and eosin staining. Data are presented as mean ± standard deviation. Statistical significance was determined using an unpaired Student’s t-test for weight measurements and Fisher’s exact test for incidence rates (p < 0.05 considered significant).
Results Nandrolone administration significantly increased final body weight in treated animals (Group B: 345.5 ± 15.2 g) compared to the control (Group A: 305.8 ± 12.4 g; p = 0.003). Prostate weight was markedly higher in Group B (1.50 ± 0.20 g) than in Group A (0.95 ± 0.10 g; p < 0.001). Histopathological analysis showed normal prostate architecture in all control animals (100%, 5/5), while all treated rats (100%, 15/15; p < 0.001) developed benign prostatic hyperplasia. Specific lesions in Group B included stromal fatty adhesion (73.3%, 11/15; p = 0.007) and intra-glandular bleeding (40%, 6/15; p = 0.028).
Conclusion Nandrolonedecanoate induces significant increases in body weight (13%) and prostate weight (58%), and causes a high incidence of histopathological abnormalities, including benign prostatic hyperplasia. These findings demonstrate its potent androgenic effects and substantial risk for prostatic pathology.
Methods Twenty male Wistar albino rats were divided into control (Group A, n=5) and treatment (Group B, n=15) groups. Group A received weekly intramuscular injections of peanut oil vehicle, while Group B received nandrolone decanoate (10 mg/kg body weight) weekly for 8 weeks. Body weights were recorded weekly. After euthanasia, prostate tissues were weighed and processed for histological examination using hematoxylin and eosin staining. Data are presented as mean ± standard deviation. Statistical significance was determined using an unpaired Student’s t-test for weight measurements and Fisher’s exact test for incidence rates (p < 0.05 considered significant).
Results Nandrolone administration significantly increased final body weight in treated animals (Group B: 345.5 ± 15.2 g) compared to the control (Group A: 305.8 ± 12.4 g; p = 0.003). Prostate weight was markedly higher in Group B (1.50 ± 0.20 g) than in Group A (0.95 ± 0.10 g; p < 0.001). Histopathological analysis showed normal prostate architecture in all control animals (100%, 5/5), while all treated rats (100%, 15/15; p < 0.001) developed benign prostatic hyperplasia. Specific lesions in Group B included stromal fatty adhesion (73.3%, 11/15; p = 0.007) and intra-glandular bleeding (40%, 6/15; p = 0.028).
Conclusion Nandrolonedecanoate induces significant increases in body weight (13%) and prostate weight (58%), and causes a high incidence of histopathological abnormalities, including benign prostatic hyperplasia. These findings demonstrate its potent androgenic effects and substantial risk for prostatic pathology.
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