[Home ] [Archive]    
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 3, Issue 1 (October 2017) ::
RABMS 2017, 3(1): 20-26 Back to browse issues page
The Effects of Antioxidants Supplementation on Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor and C-reactive protein Levels in Female Patients with Rheumatoid Arthritis
Sousan Kolahi , Amir Ghorbanihaghjo , Sina Raisi , Arezou Ghasmebaglou , Mahsa Jalili , Amir Teimouri Dereshki , Alireza i Khabbaz
Professor of Biochemistry, Drug Applied Research Center, Tabriz University of Medical Sciences , ghorbaniamir@hotmail.com
Abstract:   (58 Views)
Background & Aims: Rheumatoid Arthritis (RA) is one of the common autoimmune diseases with unknown etiology. It has been suggested that antioxidant supplements may play a role in inflammation perpetuating process. This study examined the influence of combined antioxidant supplementation on serum asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF) levels and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers in RA patients.
Materials & Methods: A three-month pre-post study was conducted on 40 female RA patients receiving one Selenplus capsule (Selenium 50μg, Zinc 8 mg, vitamin A 400 μg, vitamin C 125 mg and vitamin E 40 mg) daily. 5 ml venous blood samples were taken from all the participants before and after the administration period. The serum levels of ADMA, VEGF and high-sensitivity C-reactive protein (hs-CRP) were measured by standard methods.
Results: 39 out of 40 patients completed the study. In comparison with the baseline, we did not find any significant differences between serum ADMA and VEGF values before and after the intervention. The 3-month use of SelenPlus supplementation resulted in decreasing hs-CRP level (p<0.003).
Conclusion: The combined antioxidant supplements for 3 months decreased serum hs-CRP levels in RA patients that may be helpful in RA treatment. The hs-CRP reduction may due to the anti-inflammatory effects of Zinc and Selenium in SelenPlus supplement. 
 
Keywords: Rheumatoid Arthritis, Antioxidant, ADMA, VEGF, C-reactive protein
Full-Text [PDF 179 kb]   (22 Downloads)    
Type of Study: orginal article | Subject: Special
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kolahi S, Ghorbanihaghjo A, Raisi S, Ghasmebaglou A, Jalili M, Dereshki A T et al . The Effects of Antioxidants Supplementation on Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor and C-reactive protein Levels in Female Patients with Rheumatoid Arthritis. RABMS. 2017; 3 (1) :20-26
URL: http://ijrabms.umsu.ac.ir/article-1-51-en.html


Volume 3, Issue 1 (October 2017) Back to browse issues page
International Journal of Research in Applied and Basic Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3755