Volume 5, Issue 1 (February 2019)
Journal of Research in Applied and Basic Medical Sciences 2019, 5(1): 50-68 |
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Mehryar H R, Khaffafi B, Shadfar F, Khoshakhlagh H, Rezazadeh F, choobi anzali B. The Potential risk factors of Ischemic stroke incidence and mortality. Journal of Research in Applied and Basic Medical Sciences 2019; 5 (1) :50-68
URL: http://ijrabms.umsu.ac.ir/article-1-79-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-79-en.html
Hamid Reza Mehryar * 
, Behrang Khaffafi , Faezeh Shadfar , Hadi Khoshakhlagh , Farzin Rezazadeh , Babak Choobi anzali
, Behrang Khaffafi , Faezeh Shadfar , Hadi Khoshakhlagh , Farzin Rezazadeh , Babak Choobi anzali
Assistant Professor of Emergency Medicine, Clinical Research Development Unit of Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran , hamidrezamehryar2010@gmail.com
Abstract: (2849 Views)
Background & Aims: Ischemic stroke is always more common than hemorrhagic type. Approximately, 80% of the risk factors involved in the pathogenesis of stroke are modifiable. Identification and correction of these risk factors contributes to reducing the risk of stroke incidence, subsequent clinical consequences, disabilities, costs, and mortality of these patients.
Materials & Methods: In this retrospective cross-sectional study, 1,572 patients with ischemic stroke hospitalized during 2008-2015 were investigated. Patients data was collected in a questionnaire containing demographic information, drug and disease history, laboratory findings and events during hospitalization and follow-up period.
Results: Among 1,572 patients, 744 (47.3%) were male and 828 (52.7%) female. The number of patients who died during hospitalization was 252 (16%) and 453 (34.3%) died during the follow-up period. The most important modifiable risk factors for stroke incidence included smoking, hypertension, dyslipidemia, and diabetes mellitus. Also, the use of aspirin in both genders and statin consumption in males was associated with decreased rate of mortality. A series of laboratory findings, such as increased urea, creatinine, fasting blood glucose, cholesterol and neutrophil count, was associated with an increased risk of mortality as well as, decreased lymphocyte count, increased RBC, hemoglobin, platelet count, and triglyceride were associated with a reduction in stroke mortality.
Conclusion: This study confirms the results of previous studies about modifiable risk factors of ischemic stroke incidence such as diabetes, hypertension, dyslipidemia, and smoking. Laboratory findings such as neutrophil, lymphocyte, platelet count, hemoglobin, urea, RBC, lipid and glucose profiles associated with ischemic stroke mortality. Life style modification and preventive medication such as aspirin and statins reduce the risk of stroke incidence, disability and mortality of ischemic stroke in the community.
Materials & Methods: In this retrospective cross-sectional study, 1,572 patients with ischemic stroke hospitalized during 2008-2015 were investigated. Patients data was collected in a questionnaire containing demographic information, drug and disease history, laboratory findings and events during hospitalization and follow-up period.
Results: Among 1,572 patients, 744 (47.3%) were male and 828 (52.7%) female. The number of patients who died during hospitalization was 252 (16%) and 453 (34.3%) died during the follow-up period. The most important modifiable risk factors for stroke incidence included smoking, hypertension, dyslipidemia, and diabetes mellitus. Also, the use of aspirin in both genders and statin consumption in males was associated with decreased rate of mortality. A series of laboratory findings, such as increased urea, creatinine, fasting blood glucose, cholesterol and neutrophil count, was associated with an increased risk of mortality as well as, decreased lymphocyte count, increased RBC, hemoglobin, platelet count, and triglyceride were associated with a reduction in stroke mortality.
Conclusion: This study confirms the results of previous studies about modifiable risk factors of ischemic stroke incidence such as diabetes, hypertension, dyslipidemia, and smoking. Laboratory findings such as neutrophil, lymphocyte, platelet count, hemoglobin, urea, RBC, lipid and glucose profiles associated with ischemic stroke mortality. Life style modification and preventive medication such as aspirin and statins reduce the risk of stroke incidence, disability and mortality of ischemic stroke in the community.
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